New treatments in pediatric brain tumors

被引：2

作者：

Packer R.J. ^{[1
]}

Reddy A. ^{[1
]}

机构：

[1] Children's National Medical Center, Washington, DC 20010

来源：

Current Treatment Options in Neurology | 2004年 / 6卷 / 5期

关键词：

Clin Oncol; Medulloblastoma; Posterior Fossa; Pilocytic Astrocytoma; Pediatric Brain Tumor;

D O I：

10.1007/s11940-996-0029-3

中图分类号：

学科分类号：

摘要：

The management of childhood brain tumors is likeLy to change dramatically during the next few years. Current treatment has improved outcome in some types of brain tumors, but for most patients, survival rates have not changed during the past two decades. Advances in surgery, radiation therapy, and chemotherapy are likely to marginally increase survival, and possibly improve the quality of life for long-term survivors. As the molecular factors underlying childhood brain tumors are better elucidated, molecular-targeted therapy will become a major modality of treatment with the promise of not only increasing the likelihood of survival, but also decreasing treatment-related sequelae. Copyright © 2004 by Current Science Inc.

引用

页码：377 / 389

页数：12

共 33 条

[1]

Pomeroy S.L., Tamayo P., Gaasenbeek M., Et al., Prediction of central nervous system embryonal tumour outcome based on gene expression, Nature, 415, pp. 436-442, (2002)

[2]

MacDonald T.J., Brown K.M., LeFleur B., Et al., Expression profiling of medulloblastoma: PDGFRA and the RAS/MAPK pathway as therapeutic targets for metastatic disease, Nat. Gen., 29, pp. 143-152, (2001)

[3]

Thomas P.R.M., Deutsch M., Kepner J.L., Et al., Low-stage medulloblastoma: Final analysis of trial comparing standard-dose with reduced-dose neuroaxis irradiation, J. Clin. Oncol., 18, pp. 3004-3011, (2000)

[4]

Packer R.J., Goldwein J., Nicholson H.S., Et al., Treatment of children with medulloblastomas with reduced-dose craniospinal radiation therapy and adjuvant chemotherapy: A children's cancer group study, J. Clin. Oncol., 17, pp. 2127-2136, (1999)

[5]

Kortmann R.-D., Kuhl J., Timmermann B., Et al., Postoperative neoadjuvant chemotherapy before radiotherapy as compared to immediate radiotherapy followed by maintenance chemotherapy in the treatment of medulloblastoma in childhood: Results of the German prospective randomized trial HIT '91, Int. J. Radiat. Oncol. Biol. Phys., 46, pp. 269-279, (2000)

[6]

Taylor R.D., Bailey C.C., Robinson K., Et al., Results of a randomized study of preradiation chemotherapy versus radiotherapy alone for nonmetastatic medulloblastoma: The international Society of Paediatric Oncology/United Kingdom Children's Cancer Study Group PNET-3 Study, J. Clin. Oncol., 21, pp. 1581-1591, (2003)

[7]

Timmermann B., Kortmann R.-D., Kuhl J., Et al., Role of radiotherapy in the treatment of supratentorial primitive neuroectodermal tumors in childhood: Results of the prospective German brain tumor trials HIT 88/89 and 91, J. Clin. Oncol., 20, pp. 842-849, (2002)

[8]

Packer R.J., Biegel J.A., Blaney S., Et al., Atypical teratoid/ rhabdoid tumor of the central nervous system: Report on workshop, J. Pediatr. Hematol. Oncol., 24, pp. 337-342, (2002)

[9]

Biegel J.A., Kalpana G., Knudsen E.S., Et al., The role if INI1 and the SWI/SNF complex in the development of rhabdoid tumors: Meeting summary from the workshop on childhood atypical teratoid/rhabdoid tumors, Cancer Res., 62, pp. 323-328, (2002)

[10]

Fouladi M., Helton K., Dalton J., Et al., Clear cell ependymoma: A clinicopathologic and radiographic analysis of 10 patients, Cancer, 98, pp. 2232-2244, (2003)

← 1 2 3 4 →