Isolation of a Decavanadate Cluster [H2V10O28][4-picH]4·2H2O (4-pic = 4-picoline): Crystal Structure, Electrochemical Characterization, Genotoxic and Antimicrobial Studies

The studies on polyoxovanadate clusters have received considerable attentions due to their interesting structures and extensive applications in material science and medicinal chemistry. A novel decavanadate cluster with composition [H2V10O28][4-pic]4·2H2O has been synthesized in aqueous solution and characterized by spectral (FTIR, 51V NMR, EPR and Mass) and electrochemical studies. Single crystal X-ray crystallographic investigations indicate that decavanadate anion [H2V10O28]4− and the protonated counter cations (4-picH+) stabilize the crystal lattice giving a 2D sheet consolidated via extensive H-bonding interactions. Cyclic voltammetric studies indicate formation of stable quasi-reversible redox couple VV⇌VIV\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$ \left( {{\text{V}}^{\text{V}} \overset {} \rightleftharpoons {\text{V}}^{\text{IV}} } \right) $$\end{document} in solution. The genotoxic studies employing single cell gel electrophoresis and plasmid nicking assay ascertained the non toxic nature of the compound. The complex has also been tested for in vitro antimicrobial activities against gram +ve and gram −ve bacteria and fungi. The compound can thus be exploited as antimicrobial agent since it does not cause any toxicity or damage to DNA.