Treatment of critical-sized bone defects: clinical and tissue engineering perspectives

被引：303
作者：
Roddy E. [1 ]
DeBaun M.R. [2 ]
Daoud-Gray A. [3 ]
Yang Y.P. [4 ,5 ,6 ]
Gardner M.J. [2 ]
机构：
[1] School of Medicine, University of California, San Francisco (UCSF), 513 Parnassus Ave, San Francisco, 94143, CA
[2] Department of Orthopaedic Surgery, Stanford University, 300 Pasteur Drive, Stanford, 94305, CA
[3] School of Medicine, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, 94305, CA
[4] Department of Orthopedic Surgery, Stanford University, 300 Pasteur Drive, Stanford, 94305, CA
[5] Department of Bioengineering, Stanford University, 318 Campus Drive, Stanford, 94305, CA
[6] Department of Materials Science and Engineering, Stanford University, 300 Pasteur Drive, Stanford, 94305, CA
来源：
European Journal of Orthopaedic Surgery & Traumatology | 2018年 / 28卷 / 3期
基金：
美国国家卫生研究院;
关键词：
Bone healing; Bone tissue engineering; Critical bone defects; Fracture healing;
D O I：
10.1007/s00590-017-2063-0
中图分类号：
学科分类号：
摘要：
Critical-sized bone defects are defined as those that will not heal spontaneously within a patient’s lifetime. Current treatment options include vascularized bone grafts, distraction osteogenesis, and the induced membrane technique. The induced membrane technique is an increasingly utilized method with favorable results including high rates of union. Tissue engineering holds promise in the treatment of large bone defects due to advancement of stem cell biology, novel biomaterials, and 3D bioprinting. In this review, we provide an overview of the current operative treatment strategies of critical-sized bone defects as well as the current state of tissue engineering for such defects. © 2017, Springer-Verlag France SAS.
引用
收藏
页码：351 / 362
页数：11
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