The selective toxic effect of dialdehyde derivatives of pyrimidine nucleosides on human ovarian cancer cells

被引：3

作者：

Efremova A.S. ^{[1
]}

Shram S.I. ^{[1
]}

Drenichev M.S. ^{[2
]}

Posypanova G.A. ^{[3
]}

Myasoedov N.F. ^{[1
]}

Mikhailov S.N. ^{[2
]}

机构：

[1] Institute of Molecular Genetics, Russian Academy of Sciences, pl. Akademika Kurchatova 2, Moscow

[2] Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow

[3] Moscow Research Institute of Health and Medical Ecology, Moscow

来源：

Biochemistry (Moscow) Supplement Series B: Biomedical Chemistry | 2014年 / 8卷 / 4期

基金：

俄罗斯基础研究基金会;

关键词：

antitumor effect; cytotoxicity; dialdehyde nucleoside derivatives; human fibroblasts; human ovarian cancer cell line SKOV-3;

D O I：

10.1134/S1990750814040027

中图分类号：

学科分类号：

摘要：

The effect of synthetic nucleoside derivatives on the growth and survival of cultured human ovarian cancer cells (line SKOV-3) and normal human lung fibroblasts has been investigated. The dialdehyde derivatives of uridine, 1-β-D-erythrofuranosyl uracil and 3′-O-β-D-ribofuranosyl-2′-deoxythymidine exhibited a marked toxic effect on SKOV-3 cells, while their unoxidized analogues did not exhibit such action. Cultured human fibroblasts were less susceptible to the damaging effect of the dialdehyde nucleosides. The dialdehyde derivative of 1-β-D-erythrofuranosyl uracil demonstrated the highest difference in its cytotoxic effect on these cultures: 50% or higher suppression of SKOV-3 cells growth was achieved at the concentrations of this compound ten times lower than in the case of normal fibroblasts. © 2014, Pleiades Publishing, Ltd.

引用

页码：318 / 322

页数：4

共 21 条

[1]

Liekens S., Bronckaers A., Balzarini J., Lancet Oncol., 10, 6, pp. 628-635, (2009)

[2]

Koczor C.A., Torres R.A., Lewis W., Expert Opin. Drug Metab. Toxicol., 8, 6, pp. 665-676, (2012)

[3]

Galmarini C.M., Mackey J.R., Dumonte C., Lancet Oncol., 3, 7, pp. 415-424, (2002)

[4]

Faderl S., Gandhi V., Kantarjian H.M., Curr. Opin. Hematol., 15, 2, pp. 101-107, (2008)

[5]

Parker W.B., Chem. Rev., 109, 7, pp. 2880-2893, (2009)

[6]

Mikhailov S.N., De Clerq E., Herdewijn P., Nucleosides Nucleotides Nucleic Acids, 15, s.7–8, pp. 1323-1334, (1996)

[7]

Ermolinsky B.S., Mikhailov S.N., Rus. J. Bioorg. Chem., 26, 7, pp. 429-449, (2000)

[8]

Efimtseva E.V., Kulikova I.V., Mikhailov S.N., Current Organic Chem., 11, 4, pp. 337-354, (2007)

[9]

Efimtseva E.V., Kulikova I.V., Mikhailov S.N., Mol. Biol. (Mosk.), 43, 2, pp. 301-312, (2009)

[10]

Cory J.G., Mansell M.M., Cancer Res., 35, 2, pp. 390-396, (1975)

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