Synthesis of 5α-hydroxyecdysteroid analogs containing an isoxazole ring in the side chain

被引：0

作者：

R. P. Litvinovskaya

S. V. Drach

E. N. Masalova

V. A. Khripach

机构：

[1] National Academy of Sciences of Belarus,Institute of Bioorganic Chemistry

来源：

Russian Journal of Organic Chemistry | 2004年 / 40卷

关键词：

Migration; Steroid; Organic Chemistry; Double Bond; Hydroxy Group;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

An analog of 5α-hydroxyecdysteroids having an isoxazole ring in the side chain was synthesized starting from pregnenolone through intermediate 20-hydroxy-20-(3-isopropyl-4,5-dihydroisoxazol-5-yl) derivative. α-Bromination of 6-oxo steroids was accompanied by elimination of the hydroxy group from C20 and migration of the double bond thus formed to the heteroring to afford the corresponding 20-isoxazolyl steroid.

引用

页码：1456 / 1461

页数：5

共 15 条

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Baranovskii A.V.(1989)undefined Zh. Org. Khim. 25 1901-undefined

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Akhrem A.A.(1990)undefined Tetrahedron Lett. 30 7065-undefined

[5]

Khripach V.A.(undefined)undefined undefined undefined undefined-undefined

[6]

Litvinovskaya R.P.(undefined)undefined undefined undefined undefined-undefined

[7]

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[8]

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[9]

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[10]

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