Sputum and blood transcriptomics characterisation of the inhaled PDE4 inhibitor CHF6001 on top of triple therapy in patients with chronic bronchitis

被引：0

作者：

Mirco Govoni

Michele Bassi

Stefano Vezzoli

Germano Lucci

Aida Emirova

Marie Anna Nandeuil

Stefano Petruzzelli

Gera L. Jellema

Ebenezer K. Afolabi

Brendan Colgan

Brian Leaker

Oliver Kornmann

Kai Michael Beeh

Henrik Watz

Dave Singh

机构：

[1] Chiesi,Global Clinical Development, Personalised Medicine and Biomarkers

[2] Almac Diagnostics,Medicines Evaluation Unit

[3] Celerion,undefined

[4] The Heart Lung Centre,undefined

[5] IKF Pneumologie Frankfurt,undefined

[6] Clinical Research Centre Respiratory Diseases,undefined

[7] Insaf Respiratory Research Institute,undefined

[8] Pulmonary Research Institute at Lung Clinic Grosshansdorf,undefined

[9] Airway Research Center North (ARCN),undefined

[10] Member of the German Center for Lung Research (DZL),undefined

[11] The University of Manchester,undefined

[12] Manchester University NHS Foundation Trust,undefined

来源：

Respiratory Research | / 21卷

关键词：

Gene expression; Inflammation; Phosphodiesterase 4 inhibitors; Biomarkers; Chronic obstructive pulmonary disease;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

引用

共 9 条

[1] Sputum and blood transcriptomics characterisation of the inhaled PDE4 inhibitor CHF6001 on top of triple therapy in patients with chronic bronchitis
Govoni, Mirco
Bassi, Michele
Vezzoli, Stefano
Lucci, Germano
Emirova, Aida
Nandeuil, Marie Anna
Petruzzelli, Stefano
Jellema, Gera L.
Afolabi, Ebenezer K.
Colgan, Brendan
Leaker, Brian
Kornmann, Oliver
Beeh, Kai Michael
Watz, Henrik
Singh, Dave
RESPIRATORY RESEARCH, 2020, 21 (01)
[2] Effect of the inhaled PDE4 inhibitor CHF6001 on biomarkers of inflammation in COPD
Singh, Dave
Beeh, Kai Michael
Colgan, Brendan
Kornmann, Oliver
Leaker, Brian
Watz, Henrik
Lucci, Germano
Geraci, Silvia
Emirova, Aida
Govoni, Mirco
Nandeuil, Marie Anna
RESPIRATORY RESEARCH, 2019, 20 (01)
[3] Effect of the inhaled PDE4 inhibitor CHF6001 on biomarkers of inflammation in COPD
Dave Singh
Kai Michael Beeh
Brendan Colgan
Oliver Kornmann
Brian Leaker
Henrik Watz
Germano Lucci
Silvia Geraci
Aida Emirova
Mirco Govoni
Marie Anna Nandeuil
Respiratory Research, 20
[4] Efficacy and safety of CHF6001, a novel inhaled PDE4 inhibitor in COPD: the PIONEER study
Dave Singh
Aida Emirova
Catherine Francisco
Debora Santoro
Mirco Govoni
Marie Anna Nandeuil
Respiratory Research, 21
[5] Efficacy and safety of CHF6001, a novel inhaled PDE4 inhibitor in COPD: the PIONEER study
Singh, Dave
Emirova, Aida
Francisco, Catherine
Santoro, Debora
Govoni, Mirco
Nandeuil, Marie Anna
RESPIRATORY RESEARCH, 2020, 21 (01)
[6] Evaluation of the Effects of CHF6001, an Inhaled PDE4 Inhibitor, on Cardiac Repolarization and Cardiac Arrhythmias in Healthy Volunteers
Ferrari, Antonio
Compagnoni, Anna
Nandeuil, Anne
Maison-Blanche, Pierre
JOURNAL OF CARDIOVASCULAR PHARMACOLOGY, 2016, 68 (01) : 41 - 48
[7] Effect of CHF6001, a novel inhaled phosphodiesterase-4 inhibitor (PDE4i) on markers of inflammation in COPD patients
Singh, Dave
Govoni, Mirco
Bassi, Michele
Beeh, Kai Michael
Colgan, Brendan
Kornmann, Oliver
Laeker, Brian
Watz, Henrik
Lucci, Germano
Geraci, Silvia
Rocco, Emanuele Calabro
Emirova, Aida
Nandeuil, Marie Anna
EUROPEAN RESPIRATORY JOURNAL, 2019, 54
[8] In vitro pharmacological characterization of CHF6001, a novel selective phosphodiesterase 4 (PDE4) inhibitor with a robust anti-inflammatory profile
Facchinetti, Fabrizio
Moretto, Nadia
Caruso, Paola
Marchini, Gessica
Bosco, Raffaella
Carnini, Chiesa
Civelli, Maurizio
Villetti, Gino
EUROPEAN RESPIRATORY JOURNAL, 2014, 44
[9] COPD patients with chronic bronchitis and higher sputum eosinophil counts show increased type-2 and PDE4 gene expression in sputum
Singh, Dave
Bassi, Michele
Balzano, Deborah
Lucci, Germano
Emirova, Aida
Anna Nandeuil, Marie
Jellema, Gera
Afolabi, Ebenezer K.
Leaker, Brian
Kornmann, Oliver
Michael Beeh, Kai
Watz, Henrik
Govoni, Mirco
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, 2021, 25 (02) : 905 - 918

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