From biophysics to ‘omics and systems biology

被引:0
作者
Marko Djordjevic
Andjela Rodic
Stefan Graovac
机构
[1] University of Belgrade,Faculty of Biology, Institute of Physiology and Biochemistry
[2] University of Belgrade,Interdisciplinary PhD Program in Biophysics
来源
European Biophysics Journal | 2019年 / 48卷
关键词
Systems biology; Sequence analysis; Intracellular dynamics; Biophysical modelling; Gene expression regulation;
D O I
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中图分类号
学科分类号
摘要
Recent decades brought a revolution to biology, driven mainly by exponentially increasing amounts of data coming from “’omics” sciences. To handle these data, bioinformatics often has to combine biologically heterogeneous signals, for which methods from statistics and engineering (e.g. machine learning) are often used. While such an approach is sometimes necessary, it effectively treats the underlying biological processes as a black box. Similarly, systems biology deals with inherently complex systems, characterized by a large number of degrees of freedom, and interactions that are highly non-linear. To deal with this complexity, the underlying physical interactions are often (over)simplified, such as in Boolean modelling of network dynamics. In this review, we argue for the utility of applying a biophysical approach in bioinformatics and systems biology, including discussion of two examples from our research which address sequence analysis and understanding intracellular gene expression dynamics.
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页码:413 / 424
页数:11
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