A review of optical coherence tomography angiography (OCTA)

被引：251
作者：
de Carlo T.E. [1 ,2 ]
Romano A. [3 ,4 ]
Waheed N.K. [1 ]
Duker J.S. [1 ]
机构：
[1] New England Eye Center and Tufts Medical Center, Tufts University, 260 Tremont Street, Biewend Building, 9 - 11th Floor, Boston, 02116, MA
[2] Massachusetts Institute of Technology, Department of Electrical Engineering and Computer Science, Research Laboratory of Electronics, Cambridge, 02139, MA
[3] Federal University of São Paulo, Escola Paulista de Medicina, Department of Ophthalmology, São Paulo
[4] Retina Service, Neovista Eye Center, Americana
来源：
International Journal of Retina and Vitreous | / 1卷 / 1期
关键词：
Age-related macular degeneration; Diabetic retinopathy; Fluorescein angiography; Glaucoma; Indocyanine angiography; Optic disc; Optical coherence tomography angiography; Retina; Retinal vessel occlusion;
D O I：
10.1186/s40942-015-0005-8
中图分类号：
学科分类号：
摘要：
Optical coherence tomography angiography (OCTA) is a new, non-invasive imaging technique that generates volumetric angiography images in a matter of seconds. This is a nascent technology with a potential wide applicability for retinal vascular disease. At present, level 1 evidence of the technology's clinical applications doesn't exist. In this paper, we introduce the technology, review the available English language publications regarding OCTA, and compare it with the current angiographic gold standards, fluorescein angiography (FA) and indocyanine green angiography (ICGA). Finally we summarize its potential application to retinal vascular diseases. OCTA is quick and non-invasive, and provides volumetric data with the clinical capability of specifically localizing and delineating pathology along with the ability to show both structural and blood flow information in tandem. Its current limitations include a relatively small field of view, inability to show leakage, and proclivity for image artifact due to patient movement/blinking. Published studies hint at OCTA's potential efficacy in the evaluation of common ophthalmologic diseases such age related macular degeneration (AMD), diabetic retinopathy, artery and vein occlusions, and glaucoma. OCTA can detect changes in choroidal blood vessel flow and can elucidate the presence of choroidal neovascularization (CNV) in a variety of conditions but especially in AMD. It provides a highly detailed view of the retinal vasculature, which allows for accurate delineation of the foveal avascular zone (FAZ) in diabetic eyes and detection of subtle microvascular abnormalities in diabetic and vascular occlusive eyes. Optic disc perfusion in glaucomatous eyes is notable as well on OCTA. Further studies are needed to more definitively determine OCTA's utility in the clinical setting and to establish if this technology may offer a non-invasive option of visualizing the retinal vasculature in detail. © 2015 de Carlo et al.
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