Science review: Genetic variability in the systemic inflammatory response

被引：0
作者：
Grant W Waterer
Richard G Wunderink
机构：
[1] University of Western Australia,Senior Lecturer in Medicine, Department of Medicine
[2] University of Tennessee,Research Department,Methodist Le Bonheur Healthcare, Memphis and Clinical Associate Professor
来源：
Critical Care | / 7卷
关键词：
gene polymorphisms; genetics; inflammation; pneumonia; sepsis;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The present review discusses recent studies that have identified genetic differences in inflammatory proteins associated with different phenotypic presentations of systemic inflammation. Basic genetic terminology is defined. Implications of genetic influences on the inflammatory response are discussed. The published associations of specific polymorphisms in antigen recognition pathways, proinflammatory cytokines, anti-inflammatory cytokines, and effector molecules are reviewed. The strongest and most consistent associations thus far have been with the tumor necrosis factor, lymphotoxin-α, and IL-1 receptor antagonist polymorphisms. However, large, phenotypically detailed studies are required to address all of the other potential polymorphisms in inflammatory molecule genes and their interactions.
引用
收藏
相关论文
共 321 条
[51]  
Lien E(1995)An investigation of polymorphism in the interleukin-10 gene promoter Immunogenetics 42 444-83
[52]  
Ingalls RR(1996)A polymorphic dinucleotide repeat in the human IL-10 promoter Immunogenetics 45 82-101
[53]  
Poltorak A(2002)A second polymorphic dinucleotide repeat in the 5' flanking region of the human IL10 gene Genes Immun 3 96-277
[54]  
He X(2002)Association study between CD30 and CD30 ligand genes and type 1 diabetes in the Japanese population J Hepatol 36 271-446
[55]  
Smirnova I(1997)Polymorphisms in the interleukin-10, tumor necrosis factor-alpha, and transforming growth factor-beta1 genes in chronic hepatitis C patients treated with interferon and ribavirin Thorax 52 442-432
[56]  
Liu MY(1992)Relative production of tumour necrosis factor a and interleukin 10 in adult respiratory distress syndrome Am Rev Respir Dis 146 427-650
[57]  
VanHuffel C(2002)Elevated levels of NAP-1/Interleukin-8 are present in the airspaces of patients with the adult respiratory distress syndrome and are associated with increased mortality Am J Respir Crit Care 166 646-191
[58]  
Du X(2000)Angiotensin converting enzyme insertion/deletion polymorphism is associated with susceptibility and outcome in acute respiratory distress syndrome Clin Genet 58 181-undefined
[59]  
Birdwell D(undefined)Polymorphisms of human SP-A, SP-B, and SP-D genes: association of SP-B Thr131Ile with ARDS undefined undefined undefined-undefined
[60]  
Alejos E(undefined)undefined undefined undefined undefined-undefined
12345678910