Science review: Genetic variability in the systemic inflammatory response

被引：0
作者：
Grant W Waterer
Richard G Wunderink
机构：
[1] University of Western Australia,Senior Lecturer in Medicine, Department of Medicine
[2] University of Tennessee,Research Department,Methodist Le Bonheur Healthcare, Memphis and Clinical Associate Professor
来源：
Critical Care | / 7卷
关键词：
gene polymorphisms; genetics; inflammation; pneumonia; sepsis;
D O I：
暂无
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摘要：
The present review discusses recent studies that have identified genetic differences in inflammatory proteins associated with different phenotypic presentations of systemic inflammation. Basic genetic terminology is defined. Implications of genetic influences on the inflammatory response are discussed. The published associations of specific polymorphisms in antigen recognition pathways, proinflammatory cytokines, anti-inflammatory cytokines, and effector molecules are reviewed. The strongest and most consistent associations thus far have been with the tumor necrosis factor, lymphotoxin-α, and IL-1 receptor antagonist polymorphisms. However, large, phenotypically detailed studies are required to address all of the other potential polymorphisms in inflammatory molecule genes and their interactions.
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  • [1] Sorensen TI(1988)Genetic and environmental influences on premature death in adult adoptees N Engl J Med 318 727-732
  • [2] Nielsen GG(2000)Characterization of the effects of mutations in the putative branchpoint sequence of intron 4 on the splicing within the human lecithin:cholesterol acyltransferase gene J Biol Chem 275 18079-18084
  • [3] Andersen PK(2002)A short mutational hot spot in the first intron of BCL-6 is associated with increased BCL-6 expression and with longer overall survival in large B-cell lymphomas Am J Pathol 160 1371-1380
  • [4] Teasdale TW(1996)Sir Isaac Newton, sepsis, SIRS, and CARS Crit Care Med 24 1125-1128
  • [5] Li M(1999)Acquired immunoparalysis in paediatric intensive care: prospective observational study BMJ 319 609-610
  • [6] Pritchard PH(2002)Lipopolysaccharide recognition: CD14, TLRs and the LPS-activation cluster Trends Immunol 23 301-304
  • [7] Artiga MJ(2001)A CD14-independent LPS receptor cluster Nat Immunol 2 338-345
  • [8] Saez AI(1999)A polymorphism* in the 5' flanking region of the CD14 gene is associated with circulating soluble CD14 levels and with total serum immunoglobulin E Am J Respir Cell Mol Biol 20 976-983
  • [9] Romero C(1993)Transgenic mice expressing human CD14 are hypersensitive to lipopolysaccharide Proc Natl Acad Sci USA 90 2380-2384
  • [10] Sanchez-Beato M(2002)Association between a genomic polymorphism within the CD14 locus and septic shock susceptibility and mortality rate Crit Care Med 30 969-973
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