Cardiovascular genetics: technological advancements and applicability for dilated cardiomyopathy

被引:0
作者
G.J.M. Kummeling
A.F. Baas
M. Harakalova
J.J. van der Smagt
F.W. Asselbergs
机构
[1] University Medical Center Utrecht,Department of Cardiology, Division Heart and Lungs
[2] University Medical Center Utrecht,Department of Medical Genetics
[3] Durrer Center for Cardiogenetic Research,Faculty of Population Health Sciences, Institute of Cardiovascular Science
[4] ICIN-Netherlands Heart Institute,undefined
[5] Utrecht,undefined
[6] University College London,undefined
来源
Netherlands Heart Journal | 2015年 / 23卷
关键词
Genetics; Cardiology; Cardiomyopathy; Dilated; Review;
D O I
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中图分类号
学科分类号
摘要
Genetics plays an important role in the pathophysiology of cardiovascular diseases, and is increasingly being integrated into clinical practice. Since 2008, both capacity and cost-efficiency of mutation screening of DNA have been increased magnificently due to the technological advancement obtained by next-generation sequencing. Hence, the discovery rate of genetic defects in cardiovascular genetics has grown rapidly and the financial threshold for gene diagnostics has been lowered, making large-scale DNA sequencing broadly accessible. In this review, the genetic variants, mutations and inheritance models are briefly introduced, after which an overview is provided of current clinical and technological applications in gene diagnostics and research for cardiovascular disease and in particular, dilated cardiomyopathy. Finally, a reflection on the future perspectives in cardiogenetics is given.
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页码:356 / 362
页数:6
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