The actin cytoskeleton of kidney podocytes is a direct target of the antiproteinuric effect of cyclosporine A

被引：0

作者：

Christian Faul

Mary Donnelly

Sandra Merscher-Gomez

Yoon Hee Chang

Stefan Franz

Jacqueline Delfgaauw

Jer-Ming Chang

Hoon Young Choi

Kirk N Campbell

Kwanghee Kim

Jochen Reiser

Peter Mundel

机构：

[1] University of Miami Miller School of Medicine,Department of Medicine

[2] Mount Sinai School of Medicine,Department of Medicine

[3] One Gustave L. Levy Place,Department of Internal Medicine

[4] Hsiao-Kang Municipal Hospital,Nephrology Division and Program in Glomerular Disease, Department of Medicine

[5] Kaohsiung,undefined

[6] Medical University,undefined

[7] Massachusetts General Hospital,undefined

[8] Harvard Medical School,undefined

[9] Present addresses: Department of Medicine,undefined

[10] Yale New Haven Hospital,undefined

[11] 20 York Street,undefined

[12] New Haven,undefined

[13] Connecticut 06510,undefined

[14] USA (Y.H.C.); Roche Pharma Switzerland,undefined

[15] Schönmattstrasse 2,undefined

[16] CH-4153 Reinach,undefined

[17] Switzerland (S.F.); Development Science,undefined

[18] Grünenthal,undefined

[19] Ziegelstrasse,undefined

[20] D-52078 Aachen,undefined

[21] Germany (J.D.).,undefined

来源：

Nature Medicine | 2008年 / 14卷

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摘要：

Currently, there are few options for treating chronic kidney disease. The immunosuppressant cyclosporine A is effective, but the mechanism has been unclear. In this new report, the authors now show that the benefit of cyclosporine A is not through an effect on the immune system but rather through stabilizing the cytoskeleton, and thus the integrity, of a key cell type needed for proper kidney function.

引用

页码：931 / 938

页数：7

共 75 条

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