Validation of data on the use of twin mix in minor oral surgery: comparative evaluation of efficacy of twin mix versus 2 % lignocaine with 1:200000 epinephrine based on power analysis and an UV spectrometry study for chemical stability of the mixture

被引：11

作者：

Bhargava D. ^{[1
,4
]}

Deshpande A. ^{[2
]}

Khare P. ^{[3
]}

Pandey S.P. ^{[3
]}

Thakur N. ^{[3
]}

机构：

[1] Department of Oral and Maxillofacial Surgery, Peoples College of Dental Sciences, Peoples University, Bhanpur, Bhopal, M.P

[2] Department of Oral Medicine and Maxillofacial Radiology, Peoples Dental Academy, Bhanpur, Bhopal, M.P

[3] Department of Pharmaceutics, TRUBA Institute of Pharmacy, Karond-Gandhi Nagar By Pass Road, Bhopal, M.P

[4] Oral & Maxillofacial Surgery, H-3/2, BDA Colony, Lalghati, Airport Road, Bhopal, 462032, M.P

来源：

Oral and Maxillofacial Surgery | 2015年 / 19卷 / 1期

关键词：

Buffered local anaesthetic; Dexamethasone; Inferior alveolar nerve bock; Lignocaine; Local anaesthesia; Pterygomandibular nerve block; Third molar surgery; Transalveolar extraction; Twin mix; UV-visible spectrophotometer; Wisdom tooth removal;

D O I：

10.1007/s10006-014-0446-5

中图分类号：

学科分类号：

摘要：

Introduction: There is convincing evidence supporting the addition of dexamethasone to lignocaine and its administration as an intra-space injection to achieve benefit of a single dose steroid after third molar surgery. This study was undertaken to validate the existing data on the use of twin mix in minor oral surgery based on power analysis, statistical sample size estimation and an ultraviolet (UV) spectrometry study for chemical stability of the mixture.; Material and methods: A prospective, randomized, double-blind trial was designed to validate the pilot study on the efficacy of twin mix and 2 % lignocaine with 1:200,000 epinephrine in the surgical removal of impacted mandibular third molars. Clinical parameters of anaesthetic latency, anaesthetic duration, efficacy of twin mix as an anaesthetic and post-operative patient discomfort were assessed. The stability of active ingredients in the solution was assessed using a double beam UV-visible spectrophotometery.; Results: The results of the study showed better post-operative outcome with administration of dexamethasone and lignocaine as an intra-space injection in decreasing the post-operative patient discomfort. The anaesthetic efficacy of the twin-mix admixture was found statistically similar to the control solution of 2 % lignocaine with 1:200,000 epinephrine. The λmax recorded for dexamethasone and local anaesthetic individually was obtained with the twin-mix solution, which indicated no change in the active pharmacological compounds.; Discussion: Clinical anaesthetic efficacy of twin mix is comparable to 2 % lignocaine with 1:200,000 epinephrine when administered in the pterygomandibular space with the additional advantage of a single prick co-administration of dexamethasone with local anaesthetic, lesser sting of the local anaesthetic injection, shorter anaesthetic latency, prolonged duration of the soft tissue anaesthesia and decrease in post-operative discomfort after the oral surgical procedure. © 2014, Springer-Verlag Berlin Heidelberg.

引用

页码：37 / 41

页数：4

共 11 条

[1]

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