Oxytocin participates on the effects of vasoactive intestinal peptide on food intake and plasma parameters

被引：0
作者：
Andressa B. Martins
Marcela C. Garnica-Siqueira
Dimas A. M. Zaia
Cássia Thaïs B. V. Zaia
Ernane T. Uchôa
机构：
[1] State University of Londrina,Laboratory of Neuroendocrine Physiology and Metabolism, Department of Physiological Sciences
[2] State University of Londrina,Laboratory of Prebiotic Chemistry, Department of Chemistry
来源：
Molecular and Cellular Biochemistry | 2018年 / 437卷
关键词：
VIP; Vasotocin; Glycemia; Corticosterone; Free fatty acids;
D O I：
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学科分类号：
摘要：
Vasoactive intestinal peptide (VIP) is a neurotransmitter with anorectic effect that acts in the hypothalamus to regulate food intake. Oxytocin is a neuropeptide produced in the hypothalamus that controls energy homeostasis and has an inhibitory role on food intake. Thus, the present study aims at verifying the role of oxytocin as a mediator of VIP on energy homeostasis. For this purpose, intracerebroventricular microinjection of oxytocin receptor antagonist (vasotocin, OVT) or vehicle (NaCl 0.9%) was carried out in male rats, and after 15 min, VIP or saline was microinjected. After 15 min of the second microinjection, food intake was evaluated or euthanasia was undertaken for blood collection. There was a reduction on food intake after VIP microinjection and the pretreatment with OVT partially reversed this effect. Hyperglycemia was observed after VIP microinjection, and pretreatment with OVT partially blocked this effect. Plasma corticosterone concentration was significantly increased after VIP or OVT. Plasma levels of free fatty acids were decreased by VIP, but not when VIP was microinjected after OVT. Thus, OVT partially reversed VIP-induced hypophagia and changes on plasma metabolic parameters, suggesting a role for oxytocin as a mediator of VIP effects on energy homeostasis.
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页码：177 / 183
页数：6
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