Sinonasal SMARCB1 (INI1) Deficient Carcinoma with Yolk Sac Tumor Differentiation: A Case Report and Treatment Options

被引：0
作者：
Burak Hazir
Berkay Şímșek
Arzu Erdemír
Fatih Gürler
Ozan Yazici
Yusuf Kizil
Utku Aydíl
机构：
[1] Gazi University Hospital,Department of Otorhinolaryngology/Head and Neck Surgery
[2] Gazi University Hospital,Department of Pathology
[3] Gazi University Hospital,Department of Medical Oncology
[4] Gazi Üniversitesi Tıp Fakültesi,undefined
来源：
Head and Neck Pathology | 2022年 / 16卷
关键词：
SMARCB1; Yolk sac tumor; Sinonasal malignancies; INI-1 deficient; Paranasal sinus malignancies;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
SMARCB1 (INI1) deficient carcinoma (SDC) is a newly-described, aggressive, high-grade malignancy of the adult population. Rarely, these tumors demonstrate yolk sac differentiation. Treatment protocols are not defined due to the rarity of this entity. A 55 year-old-male presented with a tumor originating in the maxillary sinus. He was treated with neoadjuvant therapy followed by radical surgery and adjuvant treatment. We review the literature and discuss the course of disease and treatments of sinonasal SDC with yolk sac tumor differentiation. To our knowledge, this is the sixth reported case of sinonasal SDC with yolk sac tumor differentiation. This is the first publication describing the clinical course and efficacy of therapeutic interventions.
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页码：596 / 601
页数：5
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