68Ga-FAPI PET/CT for molecular assessment of fibroblast activation in right heart in pulmonary arterial hypertension: a single-center, pilot study

被引:0
作者
Yufan Gu
Kai Han
Zongyao Zhang
Zuoquan Zhao
Chaowu Yan
Lei Wang
Wei Fang
机构
[1] Chinese Academy of Medical Sciences,Department of Nuclear Medicine, Fuwai Hospital, National Center for Cardiovascular Diseases
[2] Chinese Academy of Medical Sciences,Department of Structural Heart Disease, Fuwai Hospital, National Center for Cardiovascular Diseases
来源
Journal of Nuclear Cardiology | 2023年 / 30卷
关键词
Pulmonary arterial hypertension; Ga-FAPI; PET/CT; right heart;
D O I
暂无
中图分类号
学科分类号
摘要
引用
收藏
页码:495 / 503
页数:8
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  • [1] Galie N(2015)2015 ESC/ERS Guidelines for the diagnosis and treatment of pulmonary hypertension: The Joint Task Force for the Diagnosis and Treatment of Pulmonary Hypertension of the European Society of Cardiology (ESC) and the European Respiratory Society (ERS): Endorsed by: Association for European Paediatric and Congenital Cardiology (AEPC), International Society for Heart and Lung Transplantation (ISHLT) Eur Respir J 46 903-975
  • [2] Humbert M(1980)Diastolic bulging of the interventricular septum toward the left ventricle. An echocardiographic manifestation of negative interventricular pressure gradient between left and right ventricles during diastole Circulation 62 558-563
  • [3] Vachiery JL(2006)Right ventricular function and failure: Report of a National Heart, Lung, and Blood Institute working group on cellular and molecular mechanisms of right heart failure Circulation 114 1883-1891
  • [4] Tanaka H(2019)Targeting of activated fibroblasts for imaging and therapy EJNMMI Radiopharm Chem 4 16-1422
  • [5] Tei C(2018)Development of quinoline-based theranostic ligands for the targeting of fibroblast activation protein J Nucl Med 59 1415-392
  • [6] Nakao S(2019)(68)Ga-FAPI PET/CT: Biodistribution and preliminary dosimetry estimate of 2 DOTA-containing FAP-targeting agents in patients with various cancers J Nucl Med 60 386-1749
  • [7] Voelkel NF(2019)Molecular imaging of fibroblast activity after myocardial infarction using a (68)Ga-labeled fibroblast activation protein inhibitor, FAPI-04 J Nucl Med 60 1743-1832
  • [8] Quaife RA(2018)Mechanisms of right heart disease in pulmonary hypertension (2017 Grover Conference Series) Pulm Circ 8 2045893217753121-89
  • [9] Leinwand LA(2021)Imaging of cardiac fibroblast activation in patients with chronic thromboembolic pulmonary hypertension Eur J Nucl Med Mol Imaging 49 1211-713
  • [10] Lindner T(2020)Comparison of [(68)Ga]Ga-DOTA-FAPI-04 and [(18)F] FDG PET/CT for the diagnosis of primary and metastatic lesions in patients with various types of cancer Eur J Nucl Med Mol Imaging 47 1820-203