The effects and side effects of laquinimod for the treatment of multiple sclerosis patients: a systematic review and meta-analysis of clinical trials

被引:0
作者
Faeze Rouhi
Zinat Mohammadpour
Sakineh Kazemi Noureini
Hedayat Abbastabar
Mohammad Hossein Harirchian
Sama Bitarafan
机构
[1] Hakim Sabzevari University,Department of Biology, Faculty of Basic Sciences
[2] Tehran University of Medical Sciences,Liver Transplantation Research Center, Imam Khomeini Hospital
[3] Tehran University of Medical Sciences,Iranian Center of Neurological Research, Neuroscience Institute, Imam Khomeini Hospital
来源
European Journal of Clinical Pharmacology | 2020年 / 76卷
关键词
Side effect; Laquinimod; Multiple sclerosis; Systematic review; Meta-analysis; Gadolinium-enhancing lesion; Relapse rate; Multiple sclerosis Functional Composite; Adverse event; T2 lesion; Back pain; Headache;
D O I
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学科分类号
摘要
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页码:611 / 622
页数:11
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[1]  
Constantinescu SE(2016)Laquinimod (ABR-215062) for the treatment of relapsing multiple sclerosis Expert Rev Clin Pharmacol 9 49-57
[2]  
Constantinescu CS(2013)The cost burden of multiple sclerosis in the United States: a systematic review of the literature J Med Econ 16 639-647
[3]  
Adelman G(2018)Systematic literature review and network meta-analysis of cladribine tablets versus alternative disease-modifying treatments for relapsing-remitting multiple sclerosis Curr Med Res Opin 34 1361-1371
[4]  
Rane SG(2016)Laquinimod in the treatment of multiple sclerosis: a review of the data so far Drug Des Devel Ther 10 1111-1118
[5]  
Villa KF(2017)Laquinimod safety profile: pooled analyses from the ALLEGRO and BRAVO trials Int J MS Care 19 16-24
[6]  
Siddiqui MK(2012)Laquinimod modulates B cells and their regulatory effects on T cells in multiple sclerosis J Neuroimmunol 251 45-54
[7]  
Khurana IS(2004)Laquinimod (ABR-215062) suppresses the development of experimental autoimmune encephalomyelitis, modulates the Th1/Th2 balance and induces the Th3 cytokine TGF-beta in Lewis rats J Neuroimmunol 156 3-9
[8]  
Budhia S(2010)Laquinimod interferes with migratory capacity of T cells and reduces IL-17 levels, inflammatory demyelination and acute axonal damage in mice with experimental autoimmune encephalomyelitis J Neuroimmunol 227 133-143
[9]  
Thone J(2002)Suppression of experimental autoimmune neuritis by ABR-215062 is associated with altered Th1/Th2 balance and inhibited migration of inflammatory cells into the peripheral nerve tissue Neuropharmacology 42 731-739
[10]  
Linker RA(2011)Oral treatment for multiple sclerosis Lancet Neurol 10 1026-1034