Endogenous Docosahexaenoic Acid (DHA) Prevents Aβ1–42 Oligomer-Induced Neuronal Injury

被引：0
作者：
Yuan Tan
Huixia Ren
Zhe Shi
Xiaoli Yao
Chengwei He
Jing-X Kang
Jian-Bo Wan
Peng Li
Ti-Fei Yuan
Huanxing Su
机构：
[1] University of Macau,State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences
[2] Sun Yat-Sen University,Department of Neurology, National Key Clinical Department and Key Discipline of Neurology, The First Affiliated Hospital
[3] Massachusetts General Hospital and Harvard Medical School,Laboratory for Lipid Medicine and Technology, The Department of Medicine
[4] Nanjing Normal University,School of Psychology
来源：
Molecular Neurobiology | 2016年 / 53卷
关键词：
Alzheimer’s disease; Aβ oligomers; DHA; Omega-3; Fat-1 mice;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The intake of the polyunsaturated fatty acid docosahexaenoic acid (DHA) or n-3 fatty acid has been associated with reduced risk of Alzheimer’s disease (AD) in epidemiological reports. However, the underlying mechanism remains to be elucidated. Here, we report that exogenous DHA administration could protect neurons against Aβ oligomer-induced injury both in vitro and in vivo, partly through reducing the endoplasmic reticulum (ER) stress, and preventing cell apoptosis. In transgenic fat-1 mice with enriched ω-3 fatty acids, Aβ oligomers induced fewer neuronal losses, when compared to wild-type (WT) mice. We conclude that endogenous DHA are neuroprotective in pathogenesis processes of AD.
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页码：3146 / 3153
页数：7
相关论文
共 134 条
[1]  
Haass C(2007)Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer’s amyloid beta-peptide Nat Rev Mol Cell Biol 8 101-112
[2]  
Selkoe DJ(2010)ADDLs and the signaling web that leads to Alzheimer’s disease Neuropharmacology 59 230-242
[3]  
Krafft GA(1996)Water-soluble Abeta (N-40, N-42) oligomers in normal and Alzheimer disease brains J Biol Chem 271 4077-4081
[4]  
Klein WL(1996)Morphology and toxicity of Abeta-(1-42) dimer derived from neuritic and vascular amyloid deposits of Alzheimer’s disease J Biol Chem 271 20631-20635
[5]  
Kuo YM(2000)The oligomerization of amyloid beta-protein begins intracellularly in cells derived from human brain Biochemistry 39 10831-10839
[6]  
Emmerling MR(2002)Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo Nature 416 535-539
[7]  
Vigo-Pelfrey C(2003)Alzheimer’s disease-affected brain: presence of oligomeric a beta ligands (ADDLs) suggests a molecular basis for reversible memory loss Proc Natl Acad Sci U S A 100 10417-10422
[8]  
Kasunic TC(2006)A specific amyloid-beta protein assembly in the brain impairs memory Nature 440 352-357
[9]  
Kirkpatrick JB(1997)Polyunsaturated fatty acids, antioxidants, and cognitive function in very old men Am J Epidemiol 145 33-41
[10]  
Murdoch GH(1997)Dietary fat intake and the risk of incident dementia in the Rotterdam study Ann Neurol 42 776-782
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