Structural basis for targeted DNA cytosine deamination and mutagenesis by APOBEC3A and APOBEC3B

被引：0
作者：
Ke Shi
Michael A Carpenter
Surajit Banerjee
Nadine M Shaban
Kayo Kurahashi
Daniel J Salamango
Jennifer L McCann
Gabriel J Starrett
Justin V Duffy
Özlem Demir
Rommie E Amaro
Daniel A Harki
Reuben S Harris
Hideki Aihara
机构：
[1] Molecular Biology and Biophysics,Department of Biochemistry
[2] University of Minnesota,Department of Chemistry and Biochemistry
[3] Masonic Cancer Center,Department of Medicinal Chemistry
[4] University of Minnesota,undefined
[5] Institute for Molecular Virology,undefined
[6] University of Minnesota,undefined
[7] Center for Genome Engineering,undefined
[8] University of Minnesota,undefined
[9] Howard Hughes Medical Institute,undefined
[10] University of Minnesota,undefined
[11] Northeastern Collaborative Access Team,undefined
[12] Cornell University,undefined
[13] Advanced Photon Source,undefined
[14] University of California,undefined
[15] San Diego,undefined
[16] University of Minnesota,undefined
来源：
Nature Structural & Molecular Biology | 2017年 / 24卷
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D O I：
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学科分类号：
摘要：
Crystal structures of human APOBEC3A and a chimera of APOBEC3B and APOBEC3A bound to ssDNA reveal an unanticipated ‘U-shaped’ binding mode and provide insight into target selectivity.
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页码：131 / 139
页数：8
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