The treatment of movement disorders by deep brain stimulation

被引：0
作者：
Hong Yu
Joseph S. Neimat
机构：
[1] Vanderbilt University,Department of Neurological Surgery
来源：
Neurotherapeutics | 2008年 / 5卷
关键词：
Movement disorders; Parkinson’s disease; essential tremor; dystonia; deep brain stimulation; DBS;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
It has been understood, for some time, that modulation of deep brain nuclei within the basal ganglia and thalamus can have a therapeutic effect in patients with movement disorders. Because of its reversibility and adjustability, deep brain stimulation (DBS) has largely come to replace traditional ablation procedures. The clinical effects of DBS vary, depending both on the target being stimulated and on the parameters of stimulation. Both aspects are currently the subject of substantial research and discovery. The most common targets for DBS treatment include the subthalamic nucleus for the treatment of advanced Parkinson’s disease, the ventral intermediate nucleus of the thalamus for the treatment of medically refractory essential tremor, and the globus pallidus interna for the treatment of both cervical and generalized dystonias and Parkinson’s disease. We review the current indications, targets, outcomes, and general procedure of DBS for essential tremor, Parkinson’s disease, and dystonia.
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页码：26 / 36
页数：10
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