Elevated CSF histamine levels in multiple sclerosis patients

被引：21

作者：

Kallweit U. ^{[1
]}

Aritake K. ^{[2
]}

Bassetti C.L. ^{[1
]}

Blumenthal S. ^{[3
]}

Hayaishi O. ^{[2
]}

Linnebank M. ^{[1
]}

Baumann C.R. ^{[1
]}

Urade Y. ^{[2
]}

机构：

[1] Department of Neurology, University Hospital Zurich, Frauenklinikstrasse 26, 8091 Zurich, CH

[2] Department of Molecular Behavioral Biology, Osaka Bioscience Institute, Osaka

[3] Department of Anesthesiology and Intensive Medicine, Triemli Hospital, Zurich, CH

来源：

Fluids and Barriers of the CNS | / 10卷 / 1期

关键词：

Chronic inflammatory diseases; CSF; Granulocyte-macrophage colony-stimulating factor; Histamine; Histamine receptors; Multiple sclerosis;

D O I：

10.1186/2045-8118-10-19

中图分类号：

学科分类号：

摘要：

Background: Histamine is an ubiquitous inflammatory mediator of numerous physiological processes. Histamine and its receptors have been implicated in multiple sclerosis (MS) disease pathogenesis. We prospectively enrolled 36 MS patients and 19 age and gender-matched healthy volunteers for cerebrospinal fluid (CSF) histamine analysis.Findings: CSF histamine levels in MS patient samples were significantly higher (median: 35.6 pg/ml) than in controls (median: 5.5 pg/ml; Beta = 0.525, p < 0.001). In addition, histamine increased with age (Pearson's correlation, p < 0.003).Conclusions: Histamine may be an important factor for both the initiation and maintenance of chronic inflammatory diseases of the central nervous system. Our observation encourages a deeper investigation of the role of histamine in MS. © 2013 Kallweit et al.; licensee BioMed Central Ltd.

引用

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