Elevated CSF histamine levels in multiple sclerosis patients

被引：21

作者：

Kallweit U. ^{[1
]}

Aritake K. ^{[2
]}

Bassetti C.L. ^{[1
]}

Blumenthal S. ^{[3
]}

Hayaishi O. ^{[2
]}

Linnebank M. ^{[1
]}

Baumann C.R. ^{[1
]}

Urade Y. ^{[2
]}

机构：

[1] Department of Neurology, University Hospital Zurich, Frauenklinikstrasse 26, 8091 Zurich, CH

[2] Department of Molecular Behavioral Biology, Osaka Bioscience Institute, Osaka

[3] Department of Anesthesiology and Intensive Medicine, Triemli Hospital, Zurich, CH

来源：

Fluids and Barriers of the CNS | / 10卷 / 1期

关键词：

Chronic inflammatory diseases; CSF; Granulocyte-macrophage colony-stimulating factor; Histamine; Histamine receptors; Multiple sclerosis;

D O I：

10.1186/2045-8118-10-19

中图分类号：

学科分类号：

摘要：

Background: Histamine is an ubiquitous inflammatory mediator of numerous physiological processes. Histamine and its receptors have been implicated in multiple sclerosis (MS) disease pathogenesis. We prospectively enrolled 36 MS patients and 19 age and gender-matched healthy volunteers for cerebrospinal fluid (CSF) histamine analysis.Findings: CSF histamine levels in MS patient samples were significantly higher (median: 35.6 pg/ml) than in controls (median: 5.5 pg/ml; Beta = 0.525, p < 0.001). In addition, histamine increased with age (Pearson's correlation, p < 0.003).Conclusions: Histamine may be an important factor for both the initiation and maintenance of chronic inflammatory diseases of the central nervous system. Our observation encourages a deeper investigation of the role of histamine in MS. © 2013 Kallweit et al.; licensee BioMed Central Ltd.

引用

共 16 条

[1]

Jadidi-Niaragh, F., Mirshafiey, A., Histamine and histamine receptors in pathogenesis and treatment of multiple sclerosis (2010) Neuropharmacology, 59, pp. 180-189. , 10.1016/j.neuropharm.2010.05.005, 20493888

[2]

Orr, E.L., Stanley, N.C., Brain and spinal cord levels of histamine in Lewis rats with acute experimental autoimmune encephalomyelitis (1989) J Neurochem, 53, pp. 111-118. , 10.1111/j.1471-4159.1989.tb07301.x, 2786054

[3]

Emerson, M.R., Orentas, D.M., Lynch, S.G., LeVine, S.M., Activation of histamine H2 receptors ameliorates experimental allergic encephalomyelitis (2002) Neuroreport, 13, pp. 1407-1410. , 10.1097/00001756-200208070-00012, 12167763

[4]

Lu, C., Diehl, S.A., Noubade, R., Endothelial histamine H1 receptor signaling reduces blood-brain barrier permeability and susceptibility to autoimmune encephalomyelitis (2010) Proc Natl Acad Sci U S A, 107, pp. 18967-18972. , 10.1073/pnas.1008816107, 2973887, 20956310

[5]

Stanley, N.C., Jackson, F.L., Orr, E.L., Attenuation of experimental autoimmune encephalomyelitis by compound 48/80 in Lewis rats (1990) J Neuroimmunol, 29, pp. 223-228. , 10.1016/0165-5728(90)90165-J, 2211986

[6]

Codarri, L., Gyülvészi, G., Tosevski, V., RORγt drives production of the cytokinpg/mle GM-CSF in helper T cells, which is essential for the effector phase of autoimmune neuroinflammation (2011) Nat Immunol, 12, pp. 560-567. , 10.1038/ni.2027, 21516112

[7]

Tuomisto, L., Kilpelainen, H., Riekkinen, P., Histamine and histamine-N-methyltransferase in the CSF of patients with multiple sclerosis (1983) Agents Actions, 13, pp. 255-257. , 10.1007/BF01967346, 6869128

[8]

Polman, C.H., Reingold, S.C., Edan, G., Diagnostic criteria for multiple sclerosis: 2005 revisions to the " McDonald Criteria" (2005) Ann Neurol, 58, pp. 840-846. , 10.1002/ana.20703, 16283615

[9]

Nagatsu, T., Application of high-performance liquid chromatography to the study of biogenic amine-related enzymes (1991) J Chromatogr, 566, pp. 287-307

[10]

Bassetti, C.L., Baumann, C.R., Dauvilliers, Y., Croyal, M., Robert, P., Schwartz, J.C., Cerebrospinal fluid histamine levels are decreased in patients with narcolepsy and excessive daytime sleepiness of other origin (2010) J Sleep Res, 19, pp. 620-623. , 10.1111/j.1365-2869.2010.00819.x, 20846244

← 1 2 →