Accuracy of endometrial sampling in the diagnosis of endometrial cancer: a multicenter retrospective analysis of the JAGO-NOGGO (vol 24, 380, 2024)

被引：1

作者：

Alwafai, Zaher ^{[1
,2
]}

Beck, Maximilian Heinz ^{[2
,3
,4
,5
,6
,7
,8
]}

Fazeli, Sepideh ^{[2
,9
]}

Guertler, Kathleen ^{[2
,10
]}

Kunz, Christine ^{[2
,11
]}

Singhartinger, Juliane ^{[2
,12
]}

Trojnarska, Dominika ^{[2
,13
]}

Zocholl, Dario ^{[4
,5
,14
]}

Krankenberg, David Johannes ^{[4
,5
,7
,8
]}

Blohmer, Jens-Uwe ^{[7
,8
]}

Sehouli, Jalid ^{[2
,3
,4
,5
,6
]}

Pietzner, Klaus ^{[2
,3
,4
,5
,6
]}

机构：

[1] Univ Greifswald, Dept Gynecol & Obstet, Greifswald, Germany

[2] Young Acad Gynecol Oncol JAGO, Berlin, Germany

[3] Charite Univ Med Berlin, Dept Gynecol Ctr Oncol Surg, Berlin, Germany

[4] Free Univ Berlin, Berlin, Germany

[5] Humboldt Univ, Berlin, Germany

[6] Charite Univ Med Berlin, Berlin Inst Hlth, Campus Virchow Klinikum, Berlin, Germany

[7] Charite Univ Med Berlin, Dept Gynecol Breast Ctr, Berlin, Germany

[8] Charite Univ Med Berlin, Berlin Inst Hlth, Campus Mitte, Berlin, Germany

[9] Krankenhaus Waldfriede, Klin Gynakol, Berlin, Germany

[10] DRK Kliniken Berlin Westend, Klin Gynakol, Berlin, Germany

[11] Krankenhaus St Elisabeth & Barbara, Dept Gynecol & Obstet, Halle, Germany

[12] Klinikum Traunstein, Dept Gynecol & Obstet, Traunstein, Germany

[13] Jagiellonian Univ, Med Coll, Fac Hlth & Sci, Krakow, Poland

[14] Charite Univ Med Berlin, Inst Biometry & Clin Epidemiol, Berlin, Germany

来源：

BMC CANCER | 2024年 / 24卷 / 01期

关键词：

Accuracy; Diagnosis; Endometrial cancer; Endometrial sampling;

D O I：

10.1186/s12885-024-12200-1

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background: Accurate preoperative molecular and histological risk stratification is essential for effective treatment planning in endometrial cancer. However, inconsistencies between pre- and postoperative tumor histology have been reported in previous studies. To address this issue and identify risk factors related to inaccurate histologic diagnosis after preoperative endometrial evaluation, we conducted this retrospective analysis. Methods: We conducted a retrospective analysis involving 375 patients treated for primary endometrial cancer in five different gynaecological departments in Germany. Histological assessments of curettage and hysterectomy specimens were collected and evaluated. Results: Preoperative histologic subtype was confirmed in 89.5% of cases and preoperative tumor grading in 75.2% of cases. Higher rates of histologic subtype variations (36.84%) were observed for non-endometrioid carcinomas. Non-endometrioid (OR 4.41) histology and high-grade (OR 8.37) carcinomas were identified as predictors of diverging histologic subtypes, while intermediate (OR 5.04) and high grading (OR 3.94) predicted diverging tumor grading. Conclusion: When planning therapy for endometrial cancer, the limited accuracy of endometrial sampling, especially in case of non-endometrioid histology or high tumor grading, should be carefully considered. © The Author(s) 2024.

引用

页数：1