Morfofunctional and Molecular Changes in Placenta and Peripheral Blood in Preeclampsia and Gestational Diabetes Mellitus

被引：2

作者：

Artemieva K.A. ^{[1
]}

Stepanova Y.V. ^{[2
]}

Stepanova I.I. ^{[1
]}

Shamarakova M.V. ^{[3
]}

Tikhonova N.B. ^{[1
]}

Nizyaeva N.V. ^{[1
]}

Tsakhilova S.G. ^{[2
]}

Mikhaleva L.M. ^{[1
]}

机构：

[1] Avtsyn Institute of Human Morphology, Petrovsky National Research Centre of Surgery, Moscow

[2] Evdokimov Moscow State University of Medicine and Dentistry, Moscow

[3] Yudin City Clinical Hospital, Moscow Healthcare Department, Moscow

来源：

Doklady Biological Sciences | 2023年 / 513卷 / 1期

关键词：

gestational diabetes mellitus; inflammation; placental proteins; preeclampsia; pregnancy;

D O I：

10.1134/S0012496623700722

中图分类号：

学科分类号：

摘要：

Abstract: Gestational diabetes mellitus (GDM) and preeclampsia (PE) are common pregnancy complications with similar risk factors. Although GDM is associated with PE, the exact mechanism underlying the association is unclear. The objective of this work was to study the morphofunctional and molecular changes in the placenta and peripheral blood in PE and GDM. Local and systemic changes in the production of several placental proteins were assessed along with markers of inflammation and metabolic disorders. Expression of placental lactogen, trophoblastic β1-glycoprotein, placental alpha-1-microglobulin, and proteinase 3 in villi was found to change in complicated pregnancy groups. Similarity of underlying pathogenic mechanisms was demonstrated for PE and GDM. © 2023, The Author(s).

引用

页码：387 / 394

页数：7

共 21 条

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