The endomorphin-1/2 and dynorphin-B peptides display biased agonism at the mu opioid receptor

被引：0
|
作者：
Justin LaVigne
Attila Keresztes
Daniel Chiem
John M. Streicher
机构：
[1] University of Arizona,Department of Pharmacology, College of Medicine
[2] University of New England,Department of Biomedical Sciences, College of Osteopathic Medicine
来源：
Pharmacological Reports | 2020年 / 72卷
关键词：
Endogenous opioid peptides; Endomorphin; Biased agonism; Forskolin-stimulated cAMP accumulation; S-GTPγS coupling;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
引用
收藏
页码：465 / 471
页数：6
相关论文
共 50 条
  • [21] μ-opioid receptor desensitisation and down-regulation induced by endomorphin-1
    Harrison, C
    Rowbotham, DJ
    Grandy, DK
    Lambert, DG
    BRITISH JOURNAL OF PHARMACOLOGY, 2000, 129
  • [22] Endogenous opioid peptides, endomorphin-1 and -2 and deltorphin I, stimulate angiogenesis in the CAM assay
    Dai, Xu
    Cui, Shi-gang
    Wang, Ting
    Liu, Qian
    Song, Hong-Jin
    Wang, Rui
    EUROPEAN JOURNAL OF PHARMACOLOGY, 2008, 579 (1-3) : 269 - 275
  • [23] Endomorphin-2 and endomorphin-1 promote the extracellular amount of accumbal dopamine via nonopioid and mu-opioid receptors, respectively
    Okutsu, H
    Watanabe, S
    Takahashi, I
    Aono, Y
    Saigusa, T
    Koshikawa, N
    Cools, AR
    NEUROPSYCHOPHARMACOLOGY, 2006, 31 (02) : 375 - 383
  • [24] Endomorphin-2 and Endomorphin-1 Promote the Extracellular Amount of Accumbal Dopamine via Nonopioid and Mu-Opioid Receptors, Respectively
    Hiroko Okutsu
    Shu Watanabe
    Ichiro Takahashi
    Yuri Aono
    Tadashi Saigusa
    Noriaki Koshikawa
    Alexander R Cools
    Neuropsychopharmacology, 2006, 31 : 375 - 383
  • [25] Endomorphin-1 discriminates the μ-opioid receptor from the δ- and κ-opioid receptors by recognizing the difference in multiple regions
    Ide, S
    Sakano, K
    Seki, T
    Awamura, S
    Minami, M
    Satoh, M
    JAPANESE JOURNAL OF PHARMACOLOGY, 2000, 83 (04): : 306 - 311
  • [26] Endomorphin-1 induced desensitization and down-regulation of the recombinant μ-opioid receptor
    Harrison, C
    Rowbotham, DJ
    Grandy, DK
    Lambert, DG
    BRITISH JOURNAL OF PHARMACOLOGY, 2000, 131 (06) : 1220 - 1226
  • [27] Mu opioid receptors in rat ventral medulla: effects of endomorphin-1 on phrenic nerve activity
    Lonergan, T
    Goodchild, AK
    Christie, MJ
    Pilowsky, PM
    RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY, 2003, 138 (2-3) : 165 - 178
  • [28] Mapping of reinforcing and analgesic effects of the mu opioid agonist Endomorphin-1 in the ventral midbrain of the rat
    Thomas C. Jhou
    Sheng-Ping Xu
    Mary R. Lee
    Courtney L. Gallen
    Satoshi Ikemoto
    Psychopharmacology, 2012, 224 : 303 - 312
  • [29] Mapping of reinforcing and analgesic effects of the mu opioid agonist Endomorphin-1 in the ventral midbrain of the rat
    Jhou, Thomas C.
    Xu, Sheng-Ping
    Lee, Mary R.
    Gallen, Courtney L.
    Ikemoto, Satoshi
    PSYCHOPHARMACOLOGY, 2012, 224 (02) : 303 - 312
  • [30] Systematic analysis of factors influencing observations of biased agonism at the mu-opioid receptor
    Thompson, Georgina L.
    Lane, J. Robert
    Coudrat, Thomas
    Sexton, Patrick M.
    Christopoulos, Arthur
    Canals, Meritxell
    BIOCHEMICAL PHARMACOLOGY, 2016, 113 : 70 - 87
12345