The endomorphin-1/2 and dynorphin-B peptides display biased agonism at the mu opioid receptor

[1] Kelly MA(2016)Addressing the opioid epidemic with multimodal pain management Am J Orthop (Belle Mead NJ). 45 S6-S8

[2] Wang YT(2017)Understanding the molecular basis of agonist/antagonist mechanism of human mu opioid receptor through gaussian accelerated molecular dynamics method Sci Rep. 7 7828-13

[3] Chan YH(2007)Functional selectivity and classical concepts of quantitative pharmacology J Pharmacol Exp Ther 320 1-549

[4] Urban JD(2019)A Biased view of mu-opioid receptors? Mol Pharmacol 96 542-254

[5] Clarke WP(2013)Regulation of μ-opioid receptors: desensitization, phosphorylation, internalization, and tolerance Pharmacol Rev 65 223-346

[6] von Zastrow M(2015)Biased agonism of endogenous opioid peptides at the μ-opioid receptor Mol Pharmacol 88 335-17

[7] Nichols DE(2004)Opioid receptors and their ligands Curr Top Med Chem 4 1-98

[8] Kobilka B(1995)The cloned mu, delta and kappa receptors and their endogenous ligands: evidence for two opioid peptide recognition cores Brain Res 700 89-41

[9] Weinstein H(2019)Morphine-dependent and abstinent mice are characterized by a broader distribution of the neurons co-expressing mu and delta opioid receptors Neuropharmacology 152 30-1381

[10] Conibear AE(2011)Molecular mechanisms of opioid receptor-dependent signaling and behavior Anesthesiology 115 1363-202

[1] Kelly MA(2016)Addressing the opioid epidemic with multimodal pain management Am J Orthop (Belle Mead NJ). 45 S6-S8

[2] Wang YT(2017)Understanding the molecular basis of agonist/antagonist mechanism of human mu opioid receptor through gaussian accelerated molecular dynamics method Sci Rep. 7 7828-13

[3] Chan YH(2007)Functional selectivity and classical concepts of quantitative pharmacology J Pharmacol Exp Ther 320 1-549

[4] Urban JD(2019)A Biased view of mu-opioid receptors? Mol Pharmacol 96 542-254

[5] Clarke WP(2013)Regulation of μ-opioid receptors: desensitization, phosphorylation, internalization, and tolerance Pharmacol Rev 65 223-346

[6] von Zastrow M(2015)Biased agonism of endogenous opioid peptides at the μ-opioid receptor Mol Pharmacol 88 335-17

[7] Nichols DE(2004)Opioid receptors and their ligands Curr Top Med Chem 4 1-98

[8] Kobilka B(1995)The cloned mu, delta and kappa receptors and their endogenous ligands: evidence for two opioid peptide recognition cores Brain Res 700 89-41

[9] Weinstein H(2019)Morphine-dependent and abstinent mice are characterized by a broader distribution of the neurons co-expressing mu and delta opioid receptors Neuropharmacology 152 30-1381

[10] Conibear AE(2011)Molecular mechanisms of opioid receptor-dependent signaling and behavior Anesthesiology 115 1363-202