Microsatellite polymorphism in the human heme oxygenase-1 gene promoter and its application in association studies with Alzheimer and Parkinson disease

被引：0

作者：

Teiko Kimpara

A. Takeda

Koichi Watanabe

Yasuto Itoyama

Shuntaro Ikawa

Minro Watanabe

Hiroyuki Arai

Hidetada Sasaki

Susumu Higuchi

Naoshi Okita

Sadao Takase

Hiroshi Saito

Kazuhiro Takahashi

Shigeki Shibahara

机构：

[1] Department of Neurology,

[2] Tohoku University School of Medicine,undefined

[3] 1–1 Seiryomachi,undefined

[4] Aobaku,undefined

[5] Sendai 980-77,undefined

[6] Japan Tel.: +81-22-717-7189; Fax: +81-22-717-7192 e-mail: atakeda@neurol.med.tohoku.ac.jp,undefined

[7] Department of Molecular Genetics,undefined

[8] Institute of Development,undefined

[9] Aging,undefined

[10] and Cancer,undefined

[11] Tohoku University,undefined

[12] Sendai,undefined

[13] Japan,undefined

[14] Department of Geriatrics,undefined

[15] Tohoku University School of Medicine,undefined

[16] Sendai,undefined

[17] Japan,undefined

[18] Department of Psychiatry,undefined

[19] National Institute on Alcoholism,undefined

[20] Kurihama National Hospital,undefined

[21] Kanagawa,undefined

[22] Japan,undefined

[23] Department of Neurology,undefined

[24] Kohnan Hospital,undefined

[25] Sendai,undefined

[26] Japan,undefined

[27] Department of Neurology,undefined

[28] National Nishitaga Hospital,undefined

[29] Sendai,undefined

[30] Japan,undefined

[31] Department of Applied Physiology and Molecular Biology,undefined

[32] Tohoku University School of Medicine,undefined

[33] Sendai,undefined

[34] Japan,undefined

来源：

Human Genetics | 1997年 / 100卷

关键词：

Antioxidant Enzyme; Neurodegenerative Disease; Genetic Marker; Gene Promoter; Alzheimer Disease;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Oxidative stress has been suggested to be involved in the pathogenesis of neurodegenerative diseases, such as Alzheimer disease (AD) and Parkinson disease (PD). Heme oxygenase-1 (HO-1), a key enzyme in heme catabolism, also functions as an antioxidant enzyme. Here, we show that a (GT)n repeat in the human HO-1 gene promoter region is highly polymorphic, although no particular alleles are associated with AD or PD. This newly identified genetic marker should allow us to study the possible involvement of HO-1 in certain human diseases.

引用

页码：145 / 147

页数：2