Primary care-based surveillance to estimate the burden of rotavirus gastroenteritis among children aged less than 5 years in six European countries

被引：0

作者：

Javier Diez-Domingo

Jose-Maria Baldo

Marian Patrzalek

Petr Pazdiora

Johannes Forster

Luigi Cantarutti

Jean-Yves Pirçon

Montse Soriano-Gabarró

Nadia Meyer

机构：

[1] Centro Superior de Investigación en Salud Pública (CSISP; Centre for Public Health Research),Area de Investigación en Vacunas

[2] Centro de Salud Quart de Poblet,undefined

[3] Nzoz Promed,undefined

[4] Pediatric Clinic,undefined

[5] Medical Faculty of Charles University,undefined

[6] St. Josefskrankenhaus,undefined

[7] Pedianet network,undefined

[8] GlaxoSmithKline Biologicals,undefined

来源：

European Journal of Pediatrics | 2011年 / 170卷

关键词：

Rotavirus; Gastroenteritis; Children; Epidemiology; Surveillance; Vaccination;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

This observational, prospective study was undertaken to estimate the burden of rotavirus (RV) gastroenteritis (GE) leading to general practitioner (GP)/family paediatrician (FP) visits among children aged <5 years in Czech Republic, Germany, Italy, Poland, Spain and the UK. Children aged <5 years presenting with acute GE provided stool samples for rapid RV testing. RV+ samples were confirmed and typed by RT-PCR. Demographic and clinical data were collected for all RVGE episodes. Transmission patterns among other household children aged <5 years were also assessed. From November 2005 to May 2007, excluding data from the UK, 497/3,813 (13.0%) children aged <5 years presenting with acute GE to GP/FP and tested were RV+ by PCR. Most RVGE cases (69.1%) occurred in children aged <2 years, occurred between December and May (93.1%) and were moderate or severe by Vesikari score (92.9%). RV strain distribution varied between countries: G9P[8] was the most common type in Poland (54/76) and Spain (172/196), G1P[8] was predominant in the Czech Republic (56/64) and Italy (46/107), and G4P[8] and G1P[8] both prevailed in Germany (17/54 and 13/54, respectively). A total of 24/122 (19.7%) children aged <5 years resident in the same household as a PCR+ study participant also developed RVGE. Conclusion. This multinational epidemiological study in Europe shows that RV is easily transmitted among household children, with RVGE burden highest among children aged <2 years accessing primary healthcare for acute GE.

引用

页码：213 / 222

页数：9

共 78 条

[1] Ansaldi F(2008)Burden of rotavirus-associated and non-rotavirus-associated diarrhea among nonhospitalized individuals in central Italy: a 1-year sentinel-based epidemiological and virological surveillance Clin Infect Dis 46 e51-e55
[2] Lai P(2009)G2P[4] the most prevalent rotavirus genotype in 2007 winter season in an European non-vaccinated population J Clin Virol 45 76-78
[3] Valle L(2009)Reduction in rotavirus after vaccine introduction—United States, 2000–2009 MMWR Morb Mortal Wkly Rep 58 1146-1149
[4] Antunes H(2010)Reduction in hospitalizations for diarrhea and rotavirus infections in New York state following introduction of rotavirus vaccine Vaccine 28 754-758
[5] Afonso A(2009)Decline in cases of rotavirus gastroenteritis presenting to The Children's Hospital of Philadelphia after introduction of a pentavalent rotavirus vaccine Clin Vaccine Immunol 16 382-386
[6] Iturriza M(2000)Transmission of rotavirus and other enteric pathogens in the home Pediatr Infect Dis J 19 S103-S105
[7] Chang HG(2006)Rotavirus types in Europe and their significance for vaccination Pediatr Infect Dis J 25 S30-S41
[8] Smith PF(2006)Rotavirus gastroenteritis among children under five years of age in Valencia, Spain Pediatr Infect Dis J 25 455-457
[9] Tserenpuntsag B(2008)Climatic factors associated with hospitalizations for rotavirus diarrhoea in children under 5 years of age Epidemiol Infect 136 56-64
[10] Clark HF(2009)Hospital-based surveillance to estimate the burden of rotavirus gastroenteritis among European children aged <5 years Pediatrics 123 e393-e400

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