Pluripotency of mesenchymal stem cells derived from adult marrow

被引：4336

作者：

Jiang, Yuehua ^{[1
]}

Jahagirdar, Balkrishna N. ^{[1
]}

Reinhardt, R. Lee ^{[1
]}

Schwartz, Robert E. ^{[1
]}

Keene, C. Dirk ^{[1
]}

Ortiz-Gonzalez, Xilma R. ^{[1
]}

Reyes, Morayma ^{[1
]}

Lenvik, Todd ^{[1
]}

Lund, Troy ^{[1
]}

Blackstad, Mark ^{[1
]}

Du, Jingbo ^{[1
]}

Aldrich, Sara ^{[1
]}

Lisberg, Aaron ^{[1
]}

Low, Walter C. ^{[1
]}

Lergaespada, David A. ^{[1
]}

Verfaillie, Catherine M. ^{[1
]}

机构：

[1] Stem Cell Institute, Univ. of Minnesota Medical School, Minneapolis, MN 55455, United States

来源：

Nature | 2002年 / 418卷 / 6893期

基金：

美国国家卫生研究院;

关键词：

Bone; -; Diseases; Gastroenterology; Transplantation; (surgical);

D O I：

10.1038/nature00870

中图分类号：

学科分类号：

摘要：

We report here that cells co-purifying with mesenchymal stem cells - termed here multipotent adult progenitor cells or MAPCs - differentiate, at the single cell level, not only into mesenchymal cells, but also cells with visceral mesoderm, neuroectoderm and endoderm characteristics in vitro. When injected into an early blastocyst, single MAPCs contribute to most, if not all, somatic cell types. On transplantation into a non-irradiated host, MAPCs engraft and differentiate to the haematopoietic lineage, in addition to the epithelium of liver, lung and gut. Engraftment in the haematopoietic system as well as the gastrointestinal tract is increased when MAPCs are transplanted in a minimally irradiated host. As MAPCs proliferate extensively without obvious senescence or loss of differentiation potential, they may be an ideal cell source for therapy of inherited or degenerative diseases.

引用

页码：41 / 49

页数：8

共 111 条

[41]

Morshead CM(1995)Disruption of overlapping transcripts in the ROSA beta geo 26 gene trap strain leads to widespread expression of beta-galactosidase in mouse embryos and hematopoietic cells Exp. Hematol. 23 99-395

[42]

Benveniste P(1992)Visualizing the generation of memory CD4 T cells in the whole body Proc. Natl Acad. Sci. USA 89 3290-545

[43]

Iscove NN(2001)GATA transcription factors: key regulators of hematopoiesis Nature Med. 7 393-548

[44]

van der Kooy D(2002)The nonobese diabetic scid mouse: model for spontaneous thymomagenesis associated with immunodeficiency Nature 416 542-110

[45]

Jackson K(2002)Can stem cells cross lineage boundaries? Nature 416 545-813

[46]

Mi T(2000)Bone marrow cells adopt the phenotype of other cells by spontaneous cell fusion Nature Genet. 24 109-3792

[47]

Goodell MA(1997)Changing potency by spontaneous fusion Nature 385 810-undefined

[48]

Kawada H(1998)Generation of mice from wild-type and targeted ES cells by nuclear cloning Blood 92 3780-undefined

[49]

Ogawa M(undefined)Viable offspring derived from fetal and adult mammalian cells undefined undefined undefined-undefined

[50]

Clarke DL(undefined)Efficient and rapid induction of a chronic myelogenous leukemia-like myeloproliferative disease in mice receiving P210 bcr/abl-transduced bone marrow undefined undefined undefined-undefined

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