Inhibition of Apoptosis Stages of Human Blood Lymphocytes after Exposure to Carbon Monoxide in the Presence of Recombinant Interleukin-2

被引：0
|
作者：
V. G. Artyukhov
O. I. Tyunina
机构：
[1] Voronezh State University,
[2] N. N. Burdenko Voronezh State Medical University,undefined
来源：
Bulletin of Experimental Biology and Medicine | 2017年 / 162卷
关键词：
carbon monoxide; lymphocytes; recombinant interleukin-2; Bcl-2; survivin;
D O I：
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学科分类号：
摘要：
We studied the effect of carbon monoxide (60-, 75-, and 90-min exposure) on the expression of antiapoptotic proteins (survivin and Bcl-2) in human blood lymphocytes in the presence of recombinant IL-2 in an apoptosis-inducing dose (0.1 ng/ml). Incubation of cells in atmosphere with carbon monoxide in the presence of recombinant IL-2 was accompanied by accumulation of Bcl-2 protein with simultaneous decrease of survivin content. It was concluded that carbon monoxide plays a role in the dysregulation of apoptosis of human blood lymphocytes Bcl-2 (i.e. CO inhibits the proapoptotic effect of recombinant IL-2).
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页码：362 / 365
页数：3
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