A Phase I study of MEDI-575, a PDGFRα monoclonal antibody, in Japanese patients with advanced solid tumors

[1] Ostman A(2004)PDGF receptors-mediators of autocrine tumor growth and regulators of tumor vasculature and stroma Cytokine Growth Factor Rev 15 275-286

[2] Carvalho I(2005)Overexpression of platelet-derived growth factor receptor alpha in breast cancer is associated with tumour progression Breast Cancer Res 7 R788-R795

[3] Milanezi F(2004)Biology of gastrointestinal stromal tumors J Clin Oncol 22 3813-3825

[4] Martins A(2007)Molecular mechanisms underlying FIP1L1-PDGFRA-mediated myeloproliferation Cancer Res 67 3759-3766

[5] Reis RM(2007)Platelet-derived growth factor receptor-alpha: a novel therapeutic target in human hepatocellular cancer Mol Cancer Ther 6 1932-1941

[6] Schmitt F(2004)The PDGF family: four gene products form five dimeric isoforms Cytokine Growth Factor Rev 15 197-204

[7] Corless CL(2004)Stromal fibroblasts in cancer initiation and progression Nature 432 332-337

[8] Fletcher JA(2008)Stromal myofibroblasts are drivers of invasive cancer growth Int J Cancer 123 2229-2238

[9] Heinrich MC(2006)Autocrine activation of PDGFRalpha promotes the progression of ovarian cancer Oncogene 25 2060-2069

[10] Buitenhuis M(2006)Tumor-driven paracrine platelet-derived growth factor receptor alpha signaling is a key determinant of stromal cell recruitment in a model of human lung carcinoma Clin Cancer Res 12 2676-2688

[1] Ostman A(2004)PDGF receptors-mediators of autocrine tumor growth and regulators of tumor vasculature and stroma Cytokine Growth Factor Rev 15 275-286

[2] Carvalho I(2005)Overexpression of platelet-derived growth factor receptor alpha in breast cancer is associated with tumour progression Breast Cancer Res 7 R788-R795

[3] Milanezi F(2004)Biology of gastrointestinal stromal tumors J Clin Oncol 22 3813-3825

[4] Martins A(2007)Molecular mechanisms underlying FIP1L1-PDGFRA-mediated myeloproliferation Cancer Res 67 3759-3766

[5] Reis RM(2007)Platelet-derived growth factor receptor-alpha: a novel therapeutic target in human hepatocellular cancer Mol Cancer Ther 6 1932-1941

[6] Schmitt F(2004)The PDGF family: four gene products form five dimeric isoforms Cytokine Growth Factor Rev 15 197-204

[7] Corless CL(2004)Stromal fibroblasts in cancer initiation and progression Nature 432 332-337

[8] Fletcher JA(2008)Stromal myofibroblasts are drivers of invasive cancer growth Int J Cancer 123 2229-2238

[9] Heinrich MC(2006)Autocrine activation of PDGFRalpha promotes the progression of ovarian cancer Oncogene 25 2060-2069

[10] Buitenhuis M(2006)Tumor-driven paracrine platelet-derived growth factor receptor alpha signaling is a key determinant of stromal cell recruitment in a model of human lung carcinoma Clin Cancer Res 12 2676-2688