4-Hydroxy-2-quinolones 132. Synthesis, chemical, and biological properties of 1-R-4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carboxylic acids 2-nitrobenzylidenehydrazides

被引：0

作者：

Ukrainets I.V. ^{[1
]}

Sidorenko L.V. ^{[1
]}

Golovchenko O.S. ^{[1
]}

机构：

[1] National University of Pharmacy

来源：

Chemistry of Heterocyclic Compounds | 2007年 / 43卷 / 11期

关键词：

4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carboxylic acids; Amidation; Antitubercular activity; Hydrazides; Reduction;

D O I：

10.1007/s10593-007-0221-8

中图分类号：

学科分类号：

摘要：

1-R-4-Hydroxy-2-oxo-1,2-dihydroquinoline-3-carboxylic acids 2-nitrobenzylidenehydrazides are reduced to the corresponding quinoline-3-carboxamides by zinc in glacial acetic acid but in refluxing triethylphosphite they are converted to the symmetrical N,N′-di(4-hydroxy- 2-oxo-1,2-dihydro-3-quinolinoyl)hydrazines. A study of the antitubercular activity of the synthetic compounds has been carried out. © 2007 Springer Science+Business Media, Inc.

引用

页码：1434 / 1439

页数：5

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