4-Hydroxy-2-quinolones 132. Synthesis, chemical, and biological properties of 1-R-4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carboxylic acids 2-nitrobenzylidenehydrazides

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作者
Ukrainets I.V. [1 ]
Sidorenko L.V. [1 ]
Golovchenko O.S. [1 ]
机构
[1] National University of Pharmacy
关键词
4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carboxylic acids; Amidation; Antitubercular activity; Hydrazides; Reduction;
D O I
10.1007/s10593-007-0221-8
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摘要
1-R-4-Hydroxy-2-oxo-1,2-dihydroquinoline-3-carboxylic acids 2-nitrobenzylidenehydrazides are reduced to the corresponding quinoline-3-carboxamides by zinc in glacial acetic acid but in refluxing triethylphosphite they are converted to the symmetrical N,N′-di(4-hydroxy- 2-oxo-1,2-dihydro-3-quinolinoyl)hydrazines. A study of the antitubercular activity of the synthetic compounds has been carried out. © 2007 Springer Science+Business Media, Inc.
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页码:1434 / 1439
页数:5
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