Lack of Significant Interactions Between Clopidogrel and Proton Pump Inhibitor Therapy: Meta-Analysis of Existing Literature

[1] Sibbing D(2009)Impact of proton pump inhibitors on the antiplatelet effects of clopidogrel Thromb Haemost 101 714-719

[2] Morath T(2009)Risk of adverse outcomes associated with concomitant use of clopidogrel and proton pump inhibitors following acute coronary syndrome JAMA 301 937-944

[3] Stegherr J(2008)Proton pump inhibitors effect on clopidogrel effectiveness: the clopidogrel medco outcomes study Circulation 118 S815-997

[4] Ho PM(2008)Baseline proton pump inhibitor use is associated with increased cardiovascular events with and without the use of clopidogrel in the CREDO trial Circulation 118 S815-823

[5] Maddox TM(2009)Pharmacodynamic effect and clinical efficacy of clopidogrel and prasugrel with or without a proton-pump inhibitor: an analysis of two randomised trials Lancet 374 989-188

[6] Wang L(2010)Meta-analysis: the effects of proton pump inhibitors on cardiovascular events and mortality in patients receiving clopidogrel Aliment Pharmacol Ther 31 810-1039

[7] Aubert RE(1986)Meta-analysis in clinical trials Control Clin Trials 7 177-718

[8] Epstein RS(2008)Initial assessment of clinical impact of a drug interaction between clopidogrel and proton pump inhibitors J Am Coll Cardiol 52 1038-1917

[9] Teagarden JR(2008)The impact of oral proton pump inhibitors on the effectiveness of combined aspirin and clopidogrel drug therapy during the first year after elective coronary stenting Eur Heart J 29 134-878

[10] Dunn SP(2009)Oral proton pump inhibitors and their impact on the effectiveness of dual anti-platelet therapy during the first year after elective coronary stenting J Am Coll Cardiol 53 A335-375

[1] Sibbing D(2009)Impact of proton pump inhibitors on the antiplatelet effects of clopidogrel Thromb Haemost 101 714-719

[2] Morath T(2009)Risk of adverse outcomes associated with concomitant use of clopidogrel and proton pump inhibitors following acute coronary syndrome JAMA 301 937-944

[3] Stegherr J(2008)Proton pump inhibitors effect on clopidogrel effectiveness: the clopidogrel medco outcomes study Circulation 118 S815-997

[4] Ho PM(2008)Baseline proton pump inhibitor use is associated with increased cardiovascular events with and without the use of clopidogrel in the CREDO trial Circulation 118 S815-823

[5] Maddox TM(2009)Pharmacodynamic effect and clinical efficacy of clopidogrel and prasugrel with or without a proton-pump inhibitor: an analysis of two randomised trials Lancet 374 989-188

[6] Wang L(2010)Meta-analysis: the effects of proton pump inhibitors on cardiovascular events and mortality in patients receiving clopidogrel Aliment Pharmacol Ther 31 810-1039

[7] Aubert RE(1986)Meta-analysis in clinical trials Control Clin Trials 7 177-718

[8] Epstein RS(2008)Initial assessment of clinical impact of a drug interaction between clopidogrel and proton pump inhibitors J Am Coll Cardiol 52 1038-1917

[9] Teagarden JR(2008)The impact of oral proton pump inhibitors on the effectiveness of combined aspirin and clopidogrel drug therapy during the first year after elective coronary stenting Eur Heart J 29 134-878

[10] Dunn SP(2009)Oral proton pump inhibitors and their impact on the effectiveness of dual anti-platelet therapy during the first year after elective coronary stenting J Am Coll Cardiol 53 A335-375