Synthesis and antiviral activity of novel glycyrrhizic acid conjugates with D-amino acid esters

被引：0
作者：
A. I. Fayrushina
L. A. Baltina
L. A. Baltina
N. I. Konovalova
P. A. Petrova
M. Yu. Eropkin
机构：
[1] Russian Academy of Sciences,Ufa Institute of Chemistry
[2] Ministry of Healthcare of the Russian Federation,Research Institute of Influenza
来源：
Russian Journal of Bioorganic Chemistry | 2017年 / 43卷
关键词：
glycyrrhizic acid; amino acids; conjugates; antiviral activity;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Glycyrrhizic acid (GA) conjugates with methyl and ethyl esters of D-amino acids (D-Trp, D-Phe, D-Tyr, D-Val, D-Leu) have been synthesized by the activated esters method using mixtures of N-hydroxybenzotriazole or N-hydroxysuccinimide with N,N′-dicyclohexylcarbodiimide. GA conjugate with D-Trp ethyl ester exhibited antiviral activity against influenza viruses A/H3N2, A/H1N1/pdm09, A/H5N1, B (SI > 10–29), and HRSV (SI > 25). GA conjugate with D-Trp methyl ester inhibited influenza virus A/H1N1/pdm09 (SI > 30).
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页码：456 / 462
页数：6
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