6-Hydroxydopamine: a far from simple neurotoxin

被引：0
作者：
Damir Varešlija
Keith F. Tipton
Gavin P. Davey
Andrew G. McDonald
机构：
[1] Trinity College,School of Biochemistry and Immunology
[2] Royal College of Surgeons in Ireland (RCSI),Department of Surgery
来源：
Journal of Neural Transmission | 2020年 / 127卷
关键词：
Neurotoxicity; Aminochrome; Apoptosis; Autoxidation; Dopamine; Highly reactive oxygen species (hROS); 4-Hydroxynonenal; Mitochondria; Iron release; Necrosis; Oxidative damage; Parkinson’s disease; Peroxynitrite; Reactive oxygen species (ROS);
D O I：
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学科分类号：
摘要：
6-Hydroxydopamine (6-OHDA), which is a neurotoxin that selectively destroys catecholaminergic nerves in sympathetically innervated tissues, has been used to provide a model of Parkinson’s disease in experimental animals. It is rapidly autoxidised to yield potentially toxic products and reactive oxygen species. Its ability to release Fe(II) from protein storage sites also results in the formation of hROS. This account will consider how this family of toxic products may contribute to the observed effects of 6-OHDA.
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页码：213 / 230
页数：17
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