Acid-sensing ion channels contribute to synaptic transmission and inhibit cocaine-evoked plasticity

被引：0
|
作者：
Collin J Kreple
Yuan Lu
Rebecca J Taugher
Andrea L Schwager-Gutman
Jianyang Du
Madeliene Stump
Yimo Wang
Ali Ghobbeh
Rong Fan
Caitlin V Cosme
Levi P Sowers
Michael J Welsh
Jason J Radley
Ryan T LaLumiere
John A Wemmie
机构：
[1] Medical Scientist Training Program,Department of Molecular Physiology and Biophysics
[2] University of Iowa,Department of Psychiatry
[3] University of Iowa,Department of Psychology
[4] University of Iowa,Department of Internal Medicine
[5] Interdisciplinary Graduate Program in Neuroscience,Department of Neurology
[6] University of Iowa,Department of Neurosurgery
[7] University of Iowa,undefined
[8] University of Iowa,undefined
[9] University of Iowa,undefined
[10] University of Iowa,undefined
[11] Howard Hughes Medical Institute,undefined
[12] Department of Veterans Affairs Medical Center,undefined
来源：
Nature Neuroscience | 2014年 / 17卷
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学科分类号：
摘要：
Exposure to psychostimulants such as cocaine induces synaptic plasticity within the nucleus accumbens (NAc) and alters behavior. Here the authors find a new role for the acid-sensing channel 1A (ASIC1A) in excitatory transmission and plasticity within the NAc that contributes to cocaine-induced learning and self-administration.
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页码：1083 / 1091
页数：8
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