Aminomethylation of Quercetin by Tetrahydroisoquinoline Derivatives and Their Biological Activity

被引：0
作者：
Sh. N. Zhurakulov
D. A. Narbutaeva
A. M. Karakulova
F. M. Tursunkhodzhaeva
V. I. Vinogradova
机构：
[1] Academy of Sciences of the Republic of Uzbekistan,S. Yu. Yunusov Institute of the Chemistry of Plant Substances
[2] Mirzo Ulugbek National University of Uzbekistan,undefined
来源：
Chemistry of Natural Compounds | 2023年 / 59卷
关键词：
quercetin; 1-aryltetrahydroisoquinolines; aminomethylation reaction; hypoxia;
D O I：
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学科分类号：
摘要：
Monosubstituted quercetin conjugates were synthesized via Mannich reactions from 1-aryl-(or H)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolines in 75–96% yields. Compounds with antihypoxic activity more effective than that of quercetin were found among them.
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页码：655 / 661
页数：6
相关论文
共 73 条
  • [1] Cushnie TPT(2005)Asian Int. J. Antimicrob. Agents 26 343-undefined
  • [2] Lamb AJ(1983)Asian J. Pharm Biochem. Pharmacol. 32 1141-undefined
  • [3] Havsteen B(2012)undefined Eur. J. Pharm. 684 19-undefined
  • [4] Weidmann AE(2016)undefined Chem. Nat. Compd. 52 708-undefined
  • [5] Gorbunov EB(2017)undefined J. Pharm. Pharmacol. 3 66-undefined
  • [6] Rusinov GL(2021)undefined Biomed. Pharmacol. J. 14 651-undefined
  • [7] Ulomskii EN(2022)undefined Biol. Res. 11 2231-undefined
  • [8] El′tsov OS(2022)undefined Biomed. Pharmacol. J. 15 891-undefined
  • [9] Rusinov VL(2015)undefined Chem. Nat. Compd. 51 57-undefined
  • [10] Kartsev VG(2015)undefined Khim. Interesakh Ustoich. Razvit. 23 511-undefined
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