Cytotoxic lesions of the corpus callosum after COVID-19 vaccination

被引：0
作者：
Hiroya Ohara
Hironori Shimizu
Takehito Kasamatsu
Akihiro Kajita
Kenji Uno
Khin Wee Lai
Balachandar Vellingiri
Kazuma Sugie
Masako Kinoshita
机构：
[1] Minaminara General Medical Center,Department of Neurology
[2] Nara Medical University School of Medicine,Department of Neurology
[3] Minaminara General Medical Center,Department of Infection
[4] University of Malaya,Department of Biomedical Engineering, Faculty of Engineering
[5] Bharathiar University,Department of Human Genetics and Molecular Biology
[6] National Hospital Organization Utano National Hospital,Department of Neurology
来源：
Neuroradiology | 2022年 / 64卷
关键词：
Coronavirus disease 2019; COVID-19; Cytotoxic lesions of the corpus callosum; Mild encephalitis/encephalopathy with reversible splenial lesion; COVID-19 mRNA vaccine;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
A 23-year-old previously healthy man (Patient 1) and a 33-year-old woman with a past history of depression (Patient 2) developed neurological symptoms approximately 1 week after receipt of the first COVID-19 mRNA vaccination and deteriorated over the next week. Patient 1 reported nausea, headache, a high fever, and retrograde amnesia. Patient 2 reported visual disturbance, headache, dysarthria, a left forearm tremor, dysesthesia of the mouth and distal limbs, and visual agnosia. PCR test results for SARS-CoV-2 were negative. Complete blood cell count, biochemistry, and antibody test and cerebrospinal fluid test findings were unremarkable. Diffusion-weighted and fluid-attenuated inversion recovery MRI of the brain showed a high signal intensity lesion at the midline of the splenium of the corpus callosum compatible with cytotoxic lesions of the corpus callosum (CLOCCs). High-dose intravenous methylprednisolone improved their symptoms and imaging findings. CLOCCs should be considered in patients with neurological manifestation after COVID-19 vaccination.
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页码：2085 / 2089
页数：4
相关论文
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