Topologically non-linked circular duplex DNA

被引:0
作者
Ken Biegeleisen
机构
来源
Bulletin of Mathematical Biology | 2002年 / 64卷
关键词
Helical Turn; Strand Separation; Topological Linkage; Superhelical Turn; Alkali Denaturation;
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摘要
The discovery of circular DNA, over 30 years ago, introduced an element of uneasiness in what had been, up to that point, the almost picture-perfect story of the elucidation of the molecular biology of heredity. If DNA indeed has the Watson-Crick right-handed helical secondary structure, then in circular DNA, thousands, or perhaps even millions of twists must be removed in each generation, and re-wound in the next generation.
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页码:589 / 609
页数:20
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