Homocysteine induces ferroptosis in endothelial cells through the systemXc−/GPX4 signaling pathway

[1] Deng HQ(2022)High fluid shear stress inhibits cytokine-driven Smad2/3 activation in vascular endothelial cells J Am Heart Assoc 11 e025337-7

[2] Schwartz MA(2012)Ferroptosis: An Iron-Dependent form of nonapoptotic cell death Cell 149 1060-72

[3] Dixon SJ(2020)Downregulation of folate receptor α contributes to homocysteineinduced human umbilical vein endothelial cell injury via activation of endoplasmic reticulum stress Mol Med Rep 22 1631-8

[4] Lemberg KM(2019)Homocysteine inhibits the viability and migration ability of human umbilical vein endothelial cells by downregulating the expression of vascular endothelial growth factor Exp Ther Med 18 3913-9

[5] Lamprecht MR(2020)MicroRNA-214-3p enhances erastin-induced ferroptosis by targeting ATF4 in hepatoma cells J Cell Physiol 235 5637-48

[6] Cui J(2018)Hyperhomocysteinaemia and vascular injury: advances in mechanisms and drug targets Br J Pharmacol 175 1173-89

[7] Cao C(2017)Homocysteine-reducing B vitamins and ischemic heart disease: a separate-sample mendelian randomization analysis Eur J Clin Nutr 71 267-73

[8] Hu H(2011)Glutathione peroxidase-1 in health and disease: from molecular mechanisms to therapeutic opportunities Antioxid Redox Signal 15 1957-97

[9] Zhang H(2020)Homocysteine induces oxidative stress and ferroptosis of nucleus pulposus via enhancing methylation of GPX4 Free Radic Biol Med 160 552-65

[10] Yang Y(2014)Regulation of ferroptotic cancer cell death by GPX4 Cell 156 317-31

[1] Deng HQ(2022)High fluid shear stress inhibits cytokine-driven Smad2/3 activation in vascular endothelial cells J Am Heart Assoc 11 e025337-7

[2] Schwartz MA(2012)Ferroptosis: An Iron-Dependent form of nonapoptotic cell death Cell 149 1060-72

[3] Dixon SJ(2020)Downregulation of folate receptor α contributes to homocysteineinduced human umbilical vein endothelial cell injury via activation of endoplasmic reticulum stress Mol Med Rep 22 1631-8

[4] Lemberg KM(2019)Homocysteine inhibits the viability and migration ability of human umbilical vein endothelial cells by downregulating the expression of vascular endothelial growth factor Exp Ther Med 18 3913-9

[5] Lamprecht MR(2020)MicroRNA-214-3p enhances erastin-induced ferroptosis by targeting ATF4 in hepatoma cells J Cell Physiol 235 5637-48

[6] Cui J(2018)Hyperhomocysteinaemia and vascular injury: advances in mechanisms and drug targets Br J Pharmacol 175 1173-89

[7] Cao C(2017)Homocysteine-reducing B vitamins and ischemic heart disease: a separate-sample mendelian randomization analysis Eur J Clin Nutr 71 267-73

[8] Hu H(2011)Glutathione peroxidase-1 in health and disease: from molecular mechanisms to therapeutic opportunities Antioxid Redox Signal 15 1957-97

[9] Zhang H(2020)Homocysteine induces oxidative stress and ferroptosis of nucleus pulposus via enhancing methylation of GPX4 Free Radic Biol Med 160 552-65

[10] Yang Y(2014)Regulation of ferroptotic cancer cell death by GPX4 Cell 156 317-31