Homocysteine levels in aqueous humor and plasma of patients with primary open-angle glaucoma

被引：0
作者：
J. B. Roedl
S. Bleich
U. Reulbach
N. von Ahsen
U. Schlötzer-Schrehardt
R. Rejdak
G. O. H. Naumann
F. E. Kruse
J. Kornhuber
A. G. M. Jünemann
机构：
[1] Friedrich-Alexander-University,Department of Ophthalmology and University Eye Hospital
[2] Friedrich-Alexander-University,Department of Psychiatry and Psychotherapy
[3] Friedrich-Alexander-University,Department of Medical Informatics, Biometry and Epidemiology
[4] Georg-August-University,Department of Clinical Chemistry
[5] University Eye Hospital,1st Department of Ophthalmology
[6] Polish Academy of Sciences,Medical Research Centre
来源：
Journal of Neural Transmission | 2007年 / 114卷
关键词：
Glaucoma; Homocysteine; Aqueous Humor; Hyperhomocysteinemia; Plasma Homocysteine;
D O I：
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学科分类号：
摘要：
We determined homocysteine (Hcy) levels in aqueous humor (AH) and plasma and their association with B-vitamin levels in patients with primary open-angle glaucoma (POAG) and controls. Both AH Hcy and plasma Hcy levels were significantly increased in POAG, and elevation of AH Hcy and plasma Hcy was a significant risk factor for POAG. In contrast to controls, neither plasma nor AH Hcy of POAG patients demonstrated a significant association with important non-genetic determinants of elevated Hcy such as low B-vitamin levels, increasing age and caffeine consumption. Considering that Hcy is a neurotoxin that induces apoptotic retinal ganglion cell death via stimulation of the N-methyl-D-asparate (NMDA) receptor, increased Hcy concentrations in AH and plasma might contribute to the optic nerve damage in POAG.
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页码：445 / 450
页数：5
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