The CD19 signalling molecule is elevated in NOD mice and controls type 1 diabetes development

被引:0
作者
Alexandra I. Ziegler
Melanie A. Le Page
Mhairi J. Maxwell
Jessica Stolp
Haoyao Guo
Abhirup Jayasimhan
Margaret L. Hibbs
Pere Santamaria
Jacques F. Miller
Magdalena Plebanski
Pablo A. Silveira
Robyn M. Slattery
机构
[1] Monash University,Department of Immunology
[2] Garvan Institute of Medical Research,Immunology Program
[3] University of Calgary,Julia McFarlane Diabetes Research Centre (JMDRC) and Dept of Microbiology, Immunology and Infectious Diseases, Snyder Institute for Chronic Diseases, Faculty of Medicine
[4] Institut D’Investigacions Biomediques August Pi i Sunyer,undefined
[5] Walter and Eliza Hall Institute,undefined
来源
Diabetologia | 2013年 / 56卷
关键词
B cells; CD19 signalling molecule; Invasive insulitis; Membrane-bound antigen; NOD mice; T cells; Type 1 diabetes;
D O I
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中图分类号
学科分类号
摘要
引用
收藏
页码:2659 / 2668
页数:9
相关论文
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  • [31] Charlton B(1995)Abnormal B lymphocyte development, activation, and differentiation in mice that lack or overexpress the CD19 signal transduction molecule Immunity 3 39-1040
  • [32] Gautam AM(2001)Development of type 1 diabetes despite severe hereditary B-lymphocyte deficiency N Engl J Med 345 1036-2152
  • [33] Noorchashm H(2009)Rituximab, B-lymphocyte depletion, and preservation of beta-cell function N Engl J Med 361 2143-707
  • [34] Noorchashm N(2009)Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes Nat Genet 41 703-3894
  • [35] Kern J(1994)Tissue-specific expression of the human CD19 gene in transgenic mice inhibits antigen-independent B-lymphocyte development Mol Cell Biol 14 3884-1931
  • [36] Rostami SY(1997)CD19-regulated signaling thresholds control peripheral tolerance and autoantibody production in B lymphocytes J Exp Med 186 1923-10
  • [37] Barker CF(1999)CD19 is a central response regulator of B lymphocyte signaling thresholds governing autoimmunity J Dermatol Sci 22 1-1462
  • [38] Naji A(2002)CD19-dependent B lymphocyte signaling thresholds influence skin fibrosis and autoimmunity in the tight-skin mouse J Clin Invest 109 1453-252
  • [39] Forsgren S(1998)Dendritic cells and the control of immunity Nature 392 245-363
  • [40] Andersson A(2013)Secondary T cell-T cell synaptic interactions drive the differentiation of protective CD8+ T cells Nat Immunol 14 356-402