Effect of dietary CLA supplementation on renal inflammation in diabetic mice

Dietary conjugated linoleic acid (CLA) supplementation was studied for diabetic renal inflammation improvement through modulation of inflammatory responses and oxidative stress. ICR mice were administrated alloxan (180 mg/kg, i.p.) once and fed an AIN-93G diet, or diets containing 0.5 or 1% CLA for 8 weeks. Dietary CLA supplementation did not change body weights or ameliorate fasting blood glucose, blood urea nitrogen, and kidney MDA levels. However, dietary CLA supplementation improved plasma creatinine levels and overall inflammatory response in diabetic nephropathy by modulation of phosphorylated inhibitory kappa B and the protein levels of interleukine-1β, inducible nitric oxide synthetase, and the c-reactive protein without regulation of blood glucose levels. CLA supplementation in diabetic mice did not restore the manganese superoxide dismutase antioxidant defense system. CLA supplementation was beneficial in diabetic nephropathy through regulation of inflammatory response and has potential as an antiinflammatory terapeutic in patients with mild diabetes and diabetic complications.