Body mass index modifies the relationship between γ-H2AX, a DNA damage biomarker, and pathological complete response in triple-negative breast cancer

被引:0
作者
Maddalena Barba
Patrizia Vici
Laura Pizzuti
Luigi Di Lauro
Domenico Sergi
Anna Di Benedetto
Cristiana Ercolani
Francesca Sperati
Irene Terrenato
Claudio Botti
Lucia Mentuccia
Laura Iezzi
Teresa Gamucci
Clara Natoli
Ilio Vitale
Marcella Mottolese
Ruggero De Maria
Marcello Maugeri-Saccà
机构
[1] Division of Medical Oncology 2,Department of Biology
[2] “Regina Elena” National Cancer Institute,undefined
[3] Scientific Direction,undefined
[4] “Regina Elena” National Cancer Institute,undefined
[5] Department of Pathology,undefined
[6] “Regina Elena” National Cancer Institute,undefined
[7] Biostatistics-Scientific Direction,undefined
[8] “Regina Elena” National Cancer Institute,undefined
[9] Department of Surgery,undefined
[10] “Regina Elena” National Cancer Institute,undefined
[11] Medical Oncology Unit,undefined
[12] ASL Frosinone,undefined
[13] Department of Medical,undefined
[14] Oral and Biotechnological Sciences,undefined
[15] University “G. d’Annunzio”,undefined
[16] University of Rome “Tor Vergata”,undefined
[17] Institute of General Pathology,undefined
[18] Catholic University of the Sacred Heart,undefined
来源
BMC Cancer | / 17卷
关键词
Body mass index; γ-H2AX; Chk1; Double-strand breaks; Pathological complete response; Triple-negative breast cancer;
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[11]  
Howard-McNatt M(2009)Hypoxia-inducible factors regulate tumorigenic capacity of glioma stem cells Cancer Cell 15 501-17
[12]  
Adkins F(2011)Acidic stress promotes a glioma stem cell phenotype Cell Death Differ 18 829-74
[13]  
Partin J(2014)Oxidative stress and DNA damage in obesity-related tumorigenesis Adv Exp Med Biol 824 5-33
[14]  
Hobbs G(2001)Genome maintenance mechanisms for preventing cancer Nature 411 366-112
[15]  
Kwan ML(2013)Checkpoint kinase 1 inhibitors for potentiating systemic anticancer therapy Cancer Treat Rev 39 525-36
[16]  
Kushi LH(2010)The ATM-Chk2 and ATR-Chk1 pathways in DNA damage signaling and cancer Adv Cancer Res 108 73-48
[17]  
Weltzien E(2012)DNA damage repair pathways in cancer stem cells Mol Cancer Ther 11 1627-16
[18]  
Maring B(2015)Predictive significance of DNA damage and repair biomarkers in triple-negative breast cancer patients treated with neoadjuvant chemotherapy: An exploratory analysis Oncotarget 363 1938-31
[19]  
Kutner SE(2010)Triple-negative breast cancer N Engl J Med 11 e0149872-70
[20]  
Fulton RS(2016)DNA damage and repair biomarkers in cervical cancer patients treated with neoadjuvant chemotherapy: an exploratory analysis PLoS One 8 1-91