Inhibition of 5-HT Neurotransmission Increases Clonidine Protective Effects on Naloxone-induced Conditioned Place Aversion in Morphine-dependent Rats

被引：0
作者：
Stéphanie Caillé
Luis Stinus
Emilio F Espejo
Philippe De Deurwaerdère
Umberto Spampinato
George F Koob
机构：
[1] Lab de Neuropsychobiologie des Désadaptations,Department of Neuropharmacology
[2] Université de Bordeaux II,undefined
[3] Depto de Fisiologia Médica y Biofísica,undefined
[4] Universidad de Sevilla,undefined
[5] The Scripps Research Institute,undefined
来源：
Neuropsychopharmacology | 2003年 / 28卷
关键词：
serotonin; opiate; aversion; clonidine; 8-OHDPAT;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Previous pharmacological studies have implicated serotonergic brain systems in opiate-withdrawal-precipitated conditioned place aversion. To assess this hypothesis, we tested the effects of either (i) a near-total 5,7-dihydroxytryptamine-induced lesion (90% depletion) or (ii) an acute serotonin (5-HT) inhibition induced by the specific stimulation of 5-HT1A autoreceptors (8-OHDPAT 5–100 μg/kg), on naloxone-induced conditioned place aversion in morphine-dependent rats. Morphine dependence was induced by the implantation of morphine slow-release pellets. The protective properties of clonidine (an alpha-2 adrenergic agonist classically given for opiate detoxification) were also tested after inhibition of 5-HT transmission. Serotonergic lesions in morphine-dependent rats failed to alter naloxone-induced conditioned place aversion but increased the sensitivity to the protective effects of clonidine. Acute neuropharmacological blockade of serotonin transmission also potentiated the clonidine effects on naloxone-induced conditioned place aversion. When combined with the 5-HT1A agonist 8-OHDPAT, clonidine was also found to be more potent. Further understanding of this serotonin/noradrenaline interaction might help devise new therapeutic treatments for the acute opiate withdrawal syndrome.
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页码：276 / 283
页数：7
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  • [1] Acquas E(1990)Blockade of acquisition of drug-conditioned place aversion by 5HT3 antagonists Psychopharmacology 100 459-463
  • [2] Carboni E(1985)Clonidine produces a conditioned place preference in rats Psychopharmacology 85 383-385
  • [3] Garau L(1978)An autoradiographic analysis of the differential ascending projections of the dorsal and median raphe nuclei in the rat J Comp Neurol 179 641-667
  • [4] Di Chiara G(1998)Affinities of venlafaxine and various reuptake inhibitors for the serotonin and norepinephrine transporters Eur J Pharmacol 349 129-132
  • [5] Asin KE(1997)5,7-dihydroxytryptamine lesion does not affect ethanol-induced conditioned taste and place aversion in rats Alcohol 14 439-443
  • [6] Wirtshafter D(1976)Central serotonergic mechanisms and development of morphine dependence Drug Alcohol Depend 1 221-239
  • [7] Azmitia EC(1999)Involvement of serotonin neurotransmission in opiate dependence Behav Pharmacol 10 S14-892
  • [8] Segal M(1999)Total neurochemical lesion of noradrenergic neurons of the locus coeruleus does not alter either naloxone-precipitated or spontaneous opiate withdrawal nor does it influence ability of clonidine to reverse opiate withdrawal J Pharmacol Exp Ther 290 881-274
  • [9] Beique JC(1981)Evidence of a preferential role of brain serotonin in the mechanisms leading to naloxone-precipitated compulsive jumping in morphine-dependent rats Psychopharmacology 74 271-996
  • [10] Lavoie N(1983)Evidence that 5-hydroxytryptamine in the forebrain is involved in naloxone-precipitated jumping in morphine-dependent rats Br J Pharmacol 79 993-207
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