Induced recruitment of NK cells to lymph nodes provides IFN-γ for TH1 priming

被引：0
作者：
Alfonso Martín-Fontecha
Lindy L Thomsen
Sara Brett
Craig Gerard
Martin Lipp
Antonio Lanzavecchia
Federica Sallusto
机构：
[1] Institute for Research in Biomedicine,
[2] Glaxo Smith and Kline,undefined
[3] Perlmutter Laboratory,undefined
[4] Children's Hospital and Harvard Medical School,undefined
[5] Max Delbrück Center for Molecular Medicine,undefined
来源：
Nature Immunology | 2004年 / 5卷
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摘要：
Naive T cells are stimulated by antigen-presenting dendritic cells (DCs) in secondary lymphoid organs, but whether other types of cell participate in T cell priming is unclear. Here we show in mice that natural killer (NK) cells, which are normally excluded from lymph nodes, are rapidly recruited in a CCR7-independent, CXCR3-dependent manner to lymph nodes on stimulation by the injection of mature DCs. Recruitment of NK cells is also induced by some, but not all, adjuvants and correlates with the induction of T helper cell type 1 (TH1) responses. NK cell depletion and reconstitution experiments show that NK cells provide an early source of interferon-γ (IFN-γ) that is necessary for TH1 polarization. Taken together, our results identify an induced pathway of NK cell migration in antigen-stimulated lymph nodes and a mechanism by which some adjuvants may facilitate TH1 responses.
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页码：1260 / 1265
页数：5
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