Thermodynamics of interaction of ionic liquids with lipid monolayer

被引：38
作者：
Bhattacharya G. [1 ]
Mitra S. [1 ]
Mandal P. [1 ]
Dutta S. [2 ]
Giri R.P. [3 ]
Ghosh S.K. [1 ]
机构：
[1] Department of Physics, School of Natural Sciences, Shiv Nadar University, NH-91, Tehsil Dadri, G. B. Nagar, 201314, Uttar Pradesh
[2] Department of Chemistry, School of Natural Sciences, Shiv Nadar University, NH-91, Tehsil Dadri, G. B. Nagar, 201314, Uttar Pradesh
[3] Saha Institute of Nuclear Physics, Bidhannagar, Kolkata
来源：
Biophysical Reviews | 2018年 / 10卷 / 3期
关键词：
Cellular membrane; Ionic liquids (ILs); Lipid monolayer; Thermodynamics;
D O I：
10.1007/s12551-017-0390-3
中图分类号：
学科分类号：
摘要：
Understanding the interaction of ionic liquids with cellular membrane becomes utterly important to comprehend the activities of these liquids in living organisms. Lipid monolayer formed at the air–water interface is employed as a model system to follow this interaction by investigating important thermodynamic parameters. The penetration kinetics of the imidazolium-based ionic liquid 1-decyl-3-methylimidazolium tetrafluoroborate ([DMIM][BF4]) into the zwitterionic 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC) lipid layer is found to follow the Boltzmann-like equation that reveals the characteristic time constant which is observed to be the function of initial surface pressure. The enthalpy and entropy calculated from temperature-dependent pressure–area isotherms of the monolayer show that the added ionic liquids bring about a disordering effect in the lipid film. The change in Gibbs free energy indicates that an ionic liquid with longer chain has a far greater disordering effect compared to an ionic liquid with shorter chain. The differential scanning calorimetric measurement on a multilamellar vesicle system shows the main phase transition temperature to shift to a lower value, which, again, indicates the disordering effect of the ionic liquid on lipid membrane. All these studies fundamentally point out that, when ionic liquids interact with lipid molecules, the self-assembled structure of a cellular membrane gets perturbed, which may be the mechanism of these molecules having adverse effects on living organisms. © 2018, International Union for Pure and Applied Biophysics (IUPAB) and Springer-Verlag GmbH Germany, part of Springer Nature.
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页码：709 / 719
页数：10
相关论文
共 53 条
[1]  
Aroti A., Leontidis E., Maltseva E., Brezesinski G., Effects of Hofmeister anions on DPPC Langmuir monolayers at the air−water interface, J Phys Chem B, 108, 39, pp. 15238-15245, (2004)
[2]  
Babalola G.O., Anti-bacterial activity of synthetic N-heterocyclic oxidizing compounds, Lett Appl Microbiol, 26, 1, pp. 43-46, (1998)
[3]  
Benedetto A., Room-temperature ionic liquids meet bio-membranes: the state-of-the-art, Biophys Rev, 9, 4, pp. 309-320, (2017)
[4]  
Benedetto A., Heinrich F., Gonzalez M.A., Fragneto G., Watkins E., Ballone P., Structure and stability of phospholipid bilayers hydrated by a room-temperature ionic liquid/water solution: a neutron reflectometry study, J Phys Chem B, 118, 42, pp. 12192-12206, (2014)
[5]  
Benedetto A., Bingham R.J., Ballone P., Structure and dynamics of POPC bilayers in water solutions of room temperature ionic liquids, J Chem Phys, 142, (2015)
[6]  
Bhattacharya G., Giri R.P., Saxena H., Agrawal V.V., Gupta A., Mukhopadhyay M.K., Ghosh S.K., X-ray reflectivity study of the interaction of an imidazolium-based ionic liquid with a soft supported lipid membrane, Langmuir, 33, 5, pp. 1295-1304, (2017)
[7]  
Bingham R.J., Ballone P., Computational study of room-temperature ionic liquids interacting with a POPC phospholipid bilayer, J Phys Chem B, 116, 36, pp. 11205-11216, (2012)
[8]  
Birdi K.S., Lipid and biopolymer monolayers at liquid interfaces, (2013)
[9]  
Blume A., Apparent molar heat capacities of phospholipids in aqueous dispersion. Effects of chain length and head group structure, Biochemistry, 22, 23, pp. 5436-5442, (1983)
[10]  
Byrne N., Angell C.A., Formation and dissolution of hen egg white lysozyme amyloid fibrils in protic ionic liquids, Chem Commun, 9, pp. 1046-1048, (2009)
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