Ganglioneuroma presenting as an adrenal incidentaloma: A case report

被引：15

作者：

Adas M. ^{[1
]}

Koc B. ^{[2
]}

Adas G. ^{[3
]}

Ozulker F. ^{[4
]}

Aydin T. ^{[5
]}

机构：

[1] Department of Endocrinology, Okmeydani Training and Research Hospital, 34200 Şişli, Istanbul

[2] Department of Surgery, Okmeydani Training and Research Hospital, 34200 Şişli, Istanbul

[3] Department of Surgery, Bakrkoy Training and Research Hospital, 34700 Bakrkoy, Istanbul

[4] Department of Nuclear Medicine, Okmeydani Training and Research Hospital, 34200 Şişli, Istanbul

[5] Department of Pathology, Okmeydani Training and Research Hospital, 34200 Şişli, Istanbul

来源：

Journal of Medical Case Reports | / 8卷 / 1期

关键词：

Adrenal ganglioneuroma; Adrenal gland; Incidentaloma;

D O I：

10.1186/1752-1947-8-131

中图分类号：

学科分类号：

摘要：

Introduction. Ganglioneuromas are rare benign tumors arising from the neural crest tissue and are most commonly located in the posterior mediastinum and retroperitoneum; they are rarely found in the adrenal gland. This tumor is usually asymptomatic and in the majority of cases is detected incidentally. Although the characteristics of adrenal ganglioneuroma on computerized tomography and magnetic resonance imaging have been well described, the exact diagnosis is difficult. Histopathological examination is currently the mainstay of diagnosis. Ganglioneuromas have a very good prognosis with surgical removal. We report the case of a male patient with an incidentally identified adrenal ganglioneuroma with high standardized uptake values in a positron emission tomography scan. Case presentation. An 18-year-old Turkish male patient with no previous comorbidities was admitted to our hospital with lower-quadrant pain. He had no significant past medical or surgical history. A physical examination did not reveal any signs and the results of routine laboratory tests were all within the normal ranges. Our patient underwent computed tomography of his abdomen, which showed a relatively homogenous left adrenal tumor measuring 5.2×4.3×7.1cm. On a positron emission tomography scan, the left adrenal gland disclosed a standardized uptake value of 4.1. Our patient underwent an exploratory laparotomy with left adrenalectomy without any related complications. Conclusion: Ganglioneuroma may sometimes be similar to other adrenal malignancies. Careful evaluation with endocrine tests and imaging procedures is necessary to provide an accurate diagnosis. Definitive diagnosis can be made by histological examination. The prognosis is very good with surgical removal. © 2014 Adas et al.; licensee BioMed Central Ltd.

引用

共 21 条

[1]

Geoerger B., Hero B., Harms D., Grebe J., Scheidhauer K., Berthold F., Metabolic activity and clinical features of primary ganglioneuromas, Cancer, 91, 10, pp. 1905-1913, (2001)

[2]

Erem C., Ucuncu O., Nuhoglu I., Cinel A., Cobanoglu U., Demirel A., Koc E., Kocak M., Guvendi G.F., Adrenal ganglioneuroma: Report of a new case, Endocrine, 35, pp. 293-296, (2009)

[3]

Yamaguchi K., Hara I., Takeda M., Two cases of ganglioneuroma, Urology, 67, (2006)

[4]

Qing Y., Bin X., Jian W., Li G., Linhui W., Bing L., Huiqing W., Yinghao S., Adrenal ganglioneuromas: A 10-year experience in a Chinese population, Surgery, 147, pp. 854-860, (2010)

[5]

Grumbach M.M., Biller B.M.K., Braunstein G.D., Campbell K.K., Aidan Carney J., Godley P.A., Harris E.L., Lee J.K.T., Oertel Y.C., Posner M.C., Schlechte J.A., Wieand S., Marciel K., Management of the clinically inapparent adrenal mass (incidentaloma), Annals of Internal Medicine, 138, 5, pp. 424-429, (2003)

[6]

Maweja S., Materne R., Detrembleur N., De Leval L., Defechereux T., Meurisse M., Hamoir E., Adrenal ganglioneuroma. A neoplasia to exclude in patients with adrenal incidentaloma, Acta Chir Belg, 107, pp. 670-674, (2007)

[7]

Joshi V.V., Peripheral neuroblastic tumors: Pathologic classification based on recommendations of International Neuroblastoma Pathology Committee (Modification of Shimada Classification), Pediatric and Developmental Pathology, 3, 2, pp. 184-199, (2000)

[8]

Enzinger F.M., Weiss S.W., Ganglioneuroma, Soft Tissue Tumors 3rd Edition, pp. 929-964, (1995)

[9]

Lack E.E., Tumors of the Adrenal Gland and Extra-adrenal Paraganglia, (1997)

[10]

Shahani S., Nudelman R.J., Nalini R., Kim H.S., Samson S.L., Ectopic corticotropin-releasing hormone (CRH) syndrome from metastatic small cell carcinoma: A case report and review of the literature, Diagn Pathol, 8, (2010)

← 1 2 3 →