Syntheses and radioligand activities of dimebon analogs

被引：0
作者：
A. V. Ivashchenko
O. D. Mit’kin
I. M. Okun’
I. V. Kuznetsova
机构：
[1] Chemical Diversity Research Institute,
[2] ChemDiv Inc.,undefined
来源：
Pharmaceutical Chemistry Journal | 2011年 / 45卷
关键词：
dimebon; analogs; synthesis; activity; receptors; activity profile; linkers;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Several analogs of the antihistamine drug dimebon have been synthesized with different linkers connecting a picoline fragment to the tetrahydropyridoindole core. Radioligand activity profiles of the obtained compounds have been studied using a broad set of 30 therapeutic targets. Reduction of the linker length is shown to cause substantial shifts in the activity profiles.
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页码：526 / 531
页数：5
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