Metformin reduces androgen receptor and upregulates homeobox A10 expression in uterine endometrium in women with polycystic ovary syndrome

被引：0
作者：
Miki Ohara
Hiromi Yoshida-Komiya
Miho Ono-Okutsu
Akiko Yamaguchi-Ito
Toshifumi Takahashi
Keiya Fujimori
机构：
[1] Fukushima Medical University,Department of Obstetrics and Gynecology
[2] School of Medicine,Center for Gender Specific Medicine
[3] Fukushima Medical University,Fukushima Medical Center for Children and Women
[4] Fukushima Medical University,undefined
来源：
Reproductive Biology and Endocrinology | / 19卷
关键词：
Polycystic ovary syndrome; Metformin; Uterine endometrium; Androgen receptor; Homeobox A10;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
引用
收藏
相关论文
共 174 条
  • [1] McCartney CR(2016)Polycystic ovary syndrome N Engl J Med 375 54-64
  • [2] Marshall JC(2006)Endometrium in PCOS: implantation and predisposition to endocrine CA Best Pract Res Clin Endocrinol Metab 20 235-244
  • [3] Giudice LC(2002)Effects of metformin on early pregnancy loss in the polycystic ovary syndrome J Clin Endocrinol Metab 87 524-529
  • [4] Jakubowicz DJ(2013)Cancer risk and PCOS Steroids 78 782-785
  • [5] Iuorno MJ(2002)Elevated endometrial androgen receptor expression in women with polycystic ovary syndrome Biol Reprod 66 297-304
  • [6] Jakubowicz S(2014)Endometrial progesterone resistance and PCOS J Biomed Sci 21 2-1880
  • [7] Roberts KA(1998)Effects of metformin on spontaneous and clomiphene-induced ovulation in the polycystic ovary syndrome N Engl J Med 338 1876-146
  • [8] Nestler JE(2000)Metformin effects on clinical features, endocrine and metabolic profiles, and insulin sensitivity in polycystic ovary syndrome: a randomized, double-blind, placebo-controlled 6-month trial, followed by open, long-term clinical evaluation J Clin Endocrinol Metab 85 139-953
  • [9] Dumesic DA(2003)Metformin in polycystic ovary syndrome: systematic review and meta-analysis BMJ 327 951-47
  • [10] Lobo RA(2015)Effects of metformin on endocrine, metabolic milieus and endometrial expression of androgen receptor in patients with polycystic ovary syndrome Gynecol Endocrinol 31 44-586
12345678910